{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T16:52:52Z","timestamp":1770742372632,"version":"3.49.0"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,2,22]],"date-time":"2023-02-22T00:00:00Z","timestamp":1677024000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000070","name":"National Institute of Biomedical Imaging and Bioengineering","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000070","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005270","name":"McKnight Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005270","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005393","name":"American Roentgen Ray Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005393","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neuroimaging"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Purpose<\/jats:title><jats:p>To perform a volumetric evaluation of the brain in fetuses with right or left congenital diaphragmatic hernia (CDH), and to compare brain growth trajectories to normal fetuses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We identified fetal MRIs performed between 2015 and 2020 in fetuses with a diagnosis of CDH. Gestational age (GA) range was 19\u201040 weeks. Control subjects consisted of normally developing fetuses between 19 and 40\u00a0weeks recruited for a separate prospective study. All images were acquired at 3 Tesla and were processed with retrospective motion correction and slice\u2010to\u2010volume reconstruction to generate super\u2010resolution 3\u2010dimensional volumes. These volumes were registered to a common atlas space and segmented in 29 anatomic parcellations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 174 fetal MRIs in 149 fetuses were analyzed (99 controls [mean GA: 29.2\u00a0\u00b1\u00a05.2\u00a0weeks], 34 fetuses left\u2010sided CDH [mean GA: 28.4\u00a0\u00b1\u00a05.3\u00a0weeks], and 16 fetuses right\u2010sided CDH [mean GA: 27\u00a0\u00b1\u00a05.4\u00a0weeks]). In fetuses with left\u2010sided CDH, brain parenchymal volume was \u20138.0% (95% confidence interval [CI] [\u201313.1, \u20132.5]; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.005) lower than normal controls. Differences ranged from \u201311.4% (95% CI [\u201318, \u20134.3]; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001) in the corpus callosum to \u20134.6% (95% CI [\u20138.9, \u20130.1]; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.044) in the hippocampus. In fetuses with right\u2010sided CDH, brain parenchymal volume was \u201310.1% (95% CI [\u201316.8, \u20132.7]; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.008) lower than controls. Differences ranged from \u201314.1% (95% CI [\u201321, \u20136.5]; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001) in the ventricular zone to \u20135.6% (95% CI [\u20139.3, \u20131.8]; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.025) in the brainstem.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Left and right CDH are associated with lower fetal brain volumes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jon.13096","type":"journal-article","created":{"date-parts":[[2023,2,23]],"date-time":"2023-02-23T01:58:45Z","timestamp":1677117525000},"page":"617-624","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Brain growth in fetuses with congenital diaphragmatic hernia"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3095-414X","authenticated-orcid":false,"given":"Fedel","family":"Machado\u2010Rivas","sequence":"first","affiliation":[{"name":"Department of Radiology Boston Children's Hospital  Boston Massachusetts USA"},{"name":"Department of Radiology Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jungwhan J.","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Radiology Cincinnati Children's Hospital Medical Center  Cincinnati Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Alejandra Bedoya","sequence":"additional","affiliation":[{"name":"Department of Radiology Boston Children's Hospital  Boston Massachusetts USA"},{"name":"Department of Radiology Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lina","family":"Acosta Buitrago","sequence":"additional","affiliation":[{"name":"Department of Radiology Boston Children's Hospital  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clemente","family":"Velasco\u2010Annis","sequence":"additional","affiliation":[{"name":"Department of Radiology Boston Children's Hospital  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2112-3205","authenticated-orcid":false,"given":"Onur","family":"Afacan","sequence":"additional","affiliation":[{"name":"Department of Radiology Boston Children's Hospital  Boston Massachusetts USA"},{"name":"Department of Radiology Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carol","family":"Barnewolt","sequence":"additional","affiliation":[{"name":"Department of Radiology Boston Children's Hospital  Boston Massachusetts USA"},{"name":"Department of Radiology Harvard Medical School  Boston Massachusetts 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