{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:35:31Z","timestamp":1747186531517,"version":"3.40.5"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,3,29]],"date-time":"2023-03-29T00:00:00Z","timestamp":1680048000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neuroimaging"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Purpose<\/jats:title><jats:p>Tuberculous (TB) meningitis is a common type of central nervous system infection, and may cause multifocal cerebral infarctions due to the involvement of cerebral vasculature. This systematic review aims to review and synthesize the utility of transcranial Doppler (TCD) in TB meningitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a systematic review of observational studies on the use of TCD in patients diagnosed to have TB meningitis. Study outcomes included changes in TCD parameters during stages of TB meningitis, frequency of neurologic complications (such as hydrocephalus, vasculopathy, and cerebral infarction), correlation of TCD findings with neuroimaging, and functional outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Five studies were included with a total of 141 participants, with ages from 4 months to 75 years. The most common neurologic complication was hydrocephalus (87.1%), cerebral infarction (29.2%), and arterial stenosis (26.3%). There was increased mean flow velocity (MFV) most commonly in the middle cerebral artery in the early stage of TB meningitis, and decreased MFV in the advanced disease stage. TCD findings of stenosis were well correlated with CT or MR angiogram. Among patients with hydrocephalus, pulsatility indices were significantly decreased after ventriculoperitoneal shunting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>A considerable proportion of patients with TB meningitis develop cerebral hemodynamic disturbances which lead to cerebral ischemia and affect clinical outcomes. TCD is a reliable tool for the diagnosis of vasculopathy and increased intracranial pressure and can thus help monitor disease progression and treatment response. Future studies with larger populations and longer follow\u2010ups are recommended to determine the association of TCD findings with functional outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jon.13103","type":"journal-article","created":{"date-parts":[[2023,3,30]],"date-time":"2023-03-30T04:08:42Z","timestamp":1680149322000},"page":"501-510","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Transcranial Doppler ultrasonography in tuberculous meningitis: A systematic review"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8743-7771","authenticated-orcid":false,"given":"Stephanie Patricia J.","family":"Badillo","sequence":"first","affiliation":[{"name":"Department of Neurology Zeenat Qureshi Stroke Institute Jose R. Reyes Memorial Medical Center  Manila Philippines"},{"name":"Department of Clinical Neurosciences University of the East Ramon Magsaysay Memorial Medical Center  Quezon Philippines"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose C.","family":"Navarro","sequence":"additional","affiliation":[{"name":"Department of Neurology Zeenat Qureshi Stroke Institute Jose R. Reyes Memorial Medical Center  Manila Philippines"},{"name":"Department of Neuroscience and Behavioral Medicine University of Santo Tomas Hospital  Manila Philippines"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4962-540X","authenticated-orcid":false,"given":"Adnan I.","family":"Qureshi","sequence":"additional","affiliation":[{"name":"Department of Neurology Zeenat Qureshi Stroke Institute University of Missouri  Columbia Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vijay K.","family":"Sharma","sequence":"additional","affiliation":[{"name":"YLL School of Medicine National University of Singapore and Division of Neurology National University Hospital  Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,3,29]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.12688\/wellcomeopenres.15535.1"},{"key":"e_1_2_7_3_1","first-page":"1408","article-title":"Neurologic complications of cerebral angiography","volume":"15","author":"Heiserman JE","year":"1994","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2022.841809"},{"key":"e_1_2_7_5_1","first-page":"501","article-title":"Standardized methods for enhanced quality and comparability of tuberculous meningitis studies","volume":"64","author":"Marais BJ","year":"2017","journal-title":"Clin Infect 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