{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T01:33:48Z","timestamp":1792373628919,"version":"4.4.0"},"reference-count":18,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,6,9]],"date-time":"2023-06-09T00:00:00Z","timestamp":1686268800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neuroimaging"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Purpose<\/jats:title><jats:p>The purpose of this study was to evaluate advanced MRI findings in the bilateral hippocampus CA1 region of rats with hemorrhagic shock reperfusion (HSR) and their correlation with histopathological results. Additionally, this study aimed to identify effective MRI examination methods and detection indexes for assessing HSR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Rats were randomized into the HSR and the Sham groups with 24 rats in each group. MRI examination included diffusion kurtosis imaging (DKI) and 3\u2010dimensional arterial spin labeling (3D\u2010ASL). Apoptosis and pyroptosis were evaluated directly from tissue.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the HSR group, cerebral blood flow (CBF) was significantly lower than that of the Sham group, while radial kurtosis (Kr), axial kurtosis (Ka), and mean kurtosis (MK) were all higher. In the HSR group, fractional anisotropy (FA) at 12 and 24\u00a0hours and radial diffusivity, axial diffusivity (Da), and mean diffusivity (MD) at 3 and 6\u00a0hours were lower than in the Sham group. MD and Da at 24\u00a0hours in the HSR group were significantly higher. The apoptosis rate and pyroptosis rate were also enhanced in the HSR group. CBF, FA, MK, Ka, and Kr values in the early stage were strongly correlated with apoptosis rate and pyroptosis rate. The metrics were obtained from DKI and 3D\u2010ASL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Advanced MRI metrics from DKI and 3D\u2010ASL, including CBF, FA, Ka, Kr, and MK values, are useful to evaluate abnormal blood perfusion and microstructural changes in the hippocampus CA1 area in the setting of incomplete cerebral ischemia\u2010reperfusion in rats induced by HSR.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jon.13134","type":"journal-article","created":{"date-parts":[[2023,6,9]],"date-time":"2023-06-09T14:56:53Z","timestamp":1686322613000},"page":"742-751","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Advanced MRI to assess hippocampal injury after incomplete cerebral ischemia\u2010reperfusion in rats"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-6097-5459","authenticated-orcid":false,"given":"Lan","family":"Fu","sequence":"first","affiliation":[{"name":"Department of Computed Tomography Diagnosis Cangzhou Central Hospital  Cangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li\u2010Min","family":"Zhang","sequence":"additional","affiliation":[{"name":"Anesthesia and Trauma Research Unit, Department of Anesthesiology Hebei Province Cangzhou Hospital of Integrated Traditional and Western Medicine  Cangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin\u2010Na","family":"Guan","sequence":"additional","affiliation":[{"name":"Department of Computed Tomography Diagnosis Cangzhou Central Hospital  Cangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan\u2010Cheng","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Magnetic Resonance Imaging Cangzhou Central Hospital  Cangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong\u2010Xue","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Gerontology Cangzhou Central Hospital  Cangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li\u2010Qing","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Magnetic Resonance Imaging Cangzhou Central Hospital  Cangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng\u2010Hai","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Magnetic Resonance Imaging Cangzhou Central Hospital  Cangzhou 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