{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:35:36Z","timestamp":1747186536122,"version":"3.40.5"},"reference-count":89,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,6,11]],"date-time":"2023-06-11T00:00:00Z","timestamp":1686441600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neuroimaging"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Purpose<\/jats:title><jats:p>Given the prevalence of vestibular dysfunction in pediatric concussion, there is a need to better understand pathophysiological disruptions within vestibular and associated cognitive, affective, and sensory\u2010integrative networks. Although current research leverages established intrinsic connectivity networks, these are nonspecific for vestibular function, suggesting that a pathologically guided approach is warranted. The purpose of this study was to evaluate the generalizability of the previously identified \u201cvestibular neuromatrix\u201d in adults with and without postconcussive vestibular dysfunction to young athletes aged 14\u201017.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective study leveraged resting\u2010state functional MRI data from two sites. Site A included adults with diagnosed postconcussive vestibular impairment and healthy adult controls and Site B consisted of young athletes with preseason, postconcussion, and postseason time points (prospective longitudinal data). Adjacency matrices were generated from preprocessed resting\u2010state data from each sample and assessed for overlap and network structure in MATLAB.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Analyses indicated the presence of a conserved \u201ccore\u201d network of vestibular regions as well as areas subserving visual, spatial, and attentional processing. Other vestibular connections were also conserved across samples but were not linked to the \u201ccore\u201d subnetwork by regions of interest included in this study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results suggest that connections between central vestibular, visuospatial, and known intrinsic connectivity networks are conserved across adult and pediatric participants with and without concussion, evincing the significance of this expanded, vestibular\u2010associated network. Our findings thus support this network as a workable model for investigation in future studies of dysfunction in young athlete populations.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jon.13136","type":"journal-article","created":{"date-parts":[[2023,6,12]],"date-time":"2023-06-12T06:01:01Z","timestamp":1686549661000},"page":"1003-1014","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Visuo\u2010vestibular and cognitive connections of the vestibular neuromatrix are conserved across age and injury populations"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0841-5297","authenticated-orcid":false,"given":"Jeremy L.","family":"Smith","sequence":"first","affiliation":[{"name":"Department of Radiology and Imaging Sciences Emory University School of Medicine  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jed A.","family":"Diekfuss","sequence":"additional","affiliation":[{"name":"Emory Sports Performance and Research Center (SPARC) Flowery Branch Georgia USA"},{"name":"Emory Sports Medicine Center Atlanta Georgia USA"},{"name":"Department of Orthopaedics Emory University School of Medicine Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan A.","family":"Dudley","sequence":"additional","affiliation":[{"name":"Pediatric Neuroimaging Research Consortium, Division of Radiology Cincinnati Children's Hospital Medical Center  Cincinnati Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vishwadeep","family":"Ahluwalia","sequence":"additional","affiliation":[{"name":"Georgia State University\/Georgia Tech Center for Advanced Brain Imaging (CABI)  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4622-4005","authenticated-orcid":false,"given":"Taylor M.","family":"Zuleger","sequence":"additional","affiliation":[{"name":"Emory Sports Performance and Research Center (SPARC) Flowery Branch Georgia USA"},{"name":"Emory Sports Medicine Center Atlanta Georgia USA"},{"name":"Department of Orthopaedics Emory University School of Medicine Atlanta Georgia USA"},{"name":"Neuroscience Graduate Program University of Cincinnati Cincinnati Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexis B.","family":"Slutsky\u2010Ganesh","sequence":"additional","affiliation":[{"name":"Emory Sports Performance and Research Center (SPARC) Flowery Branch Georgia USA"},{"name":"Department of Orthopaedics Emory University School of Medicine Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weihong","family":"Yuan","sequence":"additional","affiliation":[{"name":"Pediatric Neuroimaging Research Consortium, Division of Radiology Cincinnati Children's Hospital Medical Center  Cincinnati Ohio USA"},{"name":"Department of Radiology University of Cincinnati College of Medicine  Cincinnati Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kim D. 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