{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:35:38Z","timestamp":1747186538624,"version":"3.40.5"},"reference-count":37,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,9,19]],"date-time":"2023-09-19T00:00:00Z","timestamp":1695081600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100017202","name":"Fundaci\u00f3n de Investigaci\u00f3n HM Hospitales","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017202","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neuroimaging"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Purpose<\/jats:title><jats:p>The microtubule\u2010associated protein tau (MAPT) H1 homozygosity (H1\/H1 haplotype) is a genetic risk factor for neurodegenerative diseases, such as Parkinson's disease (PD). MAPT H1 homozygosity has been associated with conversion to PD; however, results are conflicting since some studies did not find a strong influence. Cortical hypometabolism is associated with cognitive impairment in PD. In this study, we aimed to evaluate the metabolic pattern in nondemented PD patients MAPT H1\/H1 carriers in comparison with MAPT H1\/H2 haplotype. In addition, we evaluated domain\u2010specific cognitive differences according to MAPT haplotype.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We compared a group of 26 H1\/H1 and 20 H1\/H2 carriers with late\u2010onset PD. Participants underwent a comprehensive neuropsychological cognitive evaluation and a [18F]\u2010Fluorodeoxyglucose PET\u2010MR scan.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>MAPT H1\/H1 carriers showed worse performance in the digit span forward test of attention compared to MAPT H1\/H2 carriers. In the [18F]\u2010Fluorodeoxyglucose PET comparisons, MAPT H1\/H1 displayed hypometabolism in the frontal cortex, parahippocampal, and cingulate gyrus, as well as in the caudate and globus pallidus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>PD patients MAPT H1\/H1 carriers without dementia exhibit relative hypometabolism in several cortical areas as well as in the basal ganglia, and worse performance in attention than MAPT H1\/H2 carriers. Longitudinal studies should assess if lower scores in attention and dysfunction in these areas are predictors of dementia in MAPT H1\/H1 homozygotes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jon.13156","type":"journal-article","created":{"date-parts":[[2023,9,20]],"date-time":"2023-09-20T04:45:20Z","timestamp":1695185120000},"page":"953-959","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Brain hypometabolism in non\u2010demented microtubule\u2010associated protein tau H1 carriers with Parkinson's disease"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7411-8106","authenticated-orcid":false,"given":"Carmen","family":"Gasca\u2010Salas","sequence":"first","affiliation":[{"name":"HM CINAC (Centro Integral de Neurociencias Abarca Campal), Hospital Universitario HM Puerta del Sur HM Hospitales  Madrid Spain"},{"name":"Network Center for Biomedical Research on Neurodegenerative 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