{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T11:13:46Z","timestamp":1772536426424,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,10,8]],"date-time":"2023-10-08T00:00:00Z","timestamp":1696723200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neuroimaging"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Purpose<\/jats:title><jats:p>To compare the accuracy of subjective Alberta Stroke Program Early CT Score (sASPECTS) evaluation and that of an automated prototype software (aASPECTS) on nonenhanced CT (NECT) in patients with early anterior territory stroke and controls using side\u2010to\u2010side quantification of hypoattenuated brain areas.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively analyzed the NECT scans of 42 consecutive patients with ischemic stroke before reperfusion and 42 controls using first sASPECTS and subsequently aASPECTS. We assessed the differences in Alberta Stroke Program Early CT Score (ASPECTS) and calculated the sensitivity and specificity of NECT with CT perfusion, whereas cerebral blood volume (CBV) served as the reference standard for brain infarction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The clot was located in the middle cerebral artery (MCA) in 47.6% of cases and the internal carotid artery (ICA) in 28.6% of cases. Ten cases presented combined ICA and MCA occlusions. The stroke was right sided in 52.4% of cases and left sided in 47.6%. Reader\u2010based NECT analysis yielded a median sASPECTS of 10. The median CBV\u2010based ASPECTS was 7. Compared to the area of decreased CBV, sASPECTS yielded a sensitivity of 12.5% and specificity of 86.8%. The software prototype (aASPECTS) yielded an overall sensitivity of 65.5% and a specificity of 92.2%. The interreader agreement for ASPECTS evaluation of admission NECT and follow\u2010up CT was almost perfect (<jats:italic>\u03ba<\/jats:italic>\u00a0=\u00a0.93). The interreader agreement of the CBV color map evaluation was substantial (<jats:italic>\u03ba<\/jats:italic>\u00a0=\u00a0.77).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>aASPECTS of NECT can outperform sASPECTS for stroke detection.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jon.13159","type":"journal-article","created":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T23:43:54Z","timestamp":1697067834000},"page":"145-151","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A novel fully automated method for measuring ASPECTS to improve stroke diagnosis: Comparison to traditional ASPECTS"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7596-5139","authenticated-orcid":false,"given":"Georg","family":"Gohla","sequence":"first","affiliation":[{"name":"Department of Diagnostic and Interventional Neuroradiology Eberhard Karls\u2010University T\u00fcbingen  T\u00fcbingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricarda","family":"Schwarz","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology Eberhard Karls\u2010University T\u00fcbingen  T\u00fcbingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georg","family":"Bier","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Neuroradiology Eberhard Karls\u2010University T\u00fcbingen  T\u00fcbingen Germany"},{"name":"Radiology Salzstra\u00dfe  Muenster Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1930-7497","authenticated-orcid":false,"given":"Arne","family":"Estler","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Neuroradiology Eberhard Karls\u2010University T\u00fcbingen  T\u00fcbingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malte N.","family":"Bongers","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology Eberhard Karls\u2010University T\u00fcbingen  T\u00fcbingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hendrik","family":"Ditt","sequence":"additional","affiliation":[{"name":"Siemens AG Healthcare; Imaging &amp; Therapy Systems Computed Tomography &amp; Radiation Oncology  Forchheim Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Fritz","sequence":"additional","affiliation":[{"name":"Russell H. 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