{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T15:42:03Z","timestamp":1791906123789,"version":"4.3.4"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T00:00:00Z","timestamp":1697328000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neuroimaging"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Purpose<\/jats:title><jats:p>Voxel\u2010based morphometry (VBM) studies of people with focal epilepsies revealed gray matter (GM) alterations in brain regions involved in cardiorespiratory regulation, which have been linked to the risk of sudden unexpected death in epilepsy (SUDEP). It remains unclear whether the type and localization of epileptogenic lesions influence the occurrence of such alterations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>To test the hypothesis that VBM alterations of autonomic network regions are independent of epileptogenic lesions and that they reveal structural underpinnings of SUDEP risk, VBM was performed in 100 people with focal epilepsies without an epileptogenic lesion identifiable on MRI (mean age \u00b1 standard deviation = 35 \u00b1 11 years, 56 female). The group was further stratified in high (sample size <jats:italic>n<\/jats:italic> = 29) and low risk of SUDEP (<jats:italic>n<\/jats:italic> = 71). GM volumes were compared between these two subgroups and to 100 matched controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>People with epilepsy displayed higher GM volume in both amygdalae and parahippocampal gyri and lower GM volume in the cerebellum and occipital (<jats:italic>p<\/jats:italic>&lt;.05, familywise error corrected). There were no significant volumetric differences between high and low SUDEP risk subgroups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings confirm that autonomic networks are structurally altered in people with focal epilepsy and they question VBM as a suitable method to show structural correlates of the SUDEP risk score.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jon.13164","type":"journal-article","created":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T03:46:14Z","timestamp":1697427974000},"page":"55-60","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Volumetric gray matter findings in autonomic network regions of people with focal epilepsy"],"prefix":"10.1111","volume":"34","author":[{"given":"Elisabeth","family":"Neuhaus","sequence":"first","affiliation":[{"name":"Department of Epileptology University Hospital Bonn  Bonn Germany"},{"name":"Department of Neurology Epilepsy Center Frankfurt Rhine\u2010Main Goethe University Frankfurt  Frankfurt am Main Germany"},{"name":"Center for Personalized Translational Epilepsy Research (CePTER) Goethe\u2010University Frankfurt  Frankfurt am Main Germany"},{"name":"Institute of Neuroradiology Goethe University Frankfurt  Frankfurt am Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Bitzer","sequence":"additional","affiliation":[{"name":"Department of Epileptology University Hospital Bonn  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina R.","family":"Held","sequence":"additional","affiliation":[{"name":"Department of Epileptology University Hospital Bonn  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Bauer","sequence":"additional","affiliation":[{"name":"Department of Epileptology University Hospital Bonn  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Gaubatz","sequence":"additional","affiliation":[{"name":"Department of Epileptology University Hospital Bonn  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randi","family":"von Wrede","sequence":"additional","affiliation":[{"name":"Department of Epileptology University Hospital Bonn  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Baumgartner","sequence":"additional","affiliation":[{"name":"Department of Epileptology University Hospital Bonn  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atilla","family":"R\u00e1cz","sequence":"additional","affiliation":[{"name":"Department of Epileptology University Hospital Bonn  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vitali","family":"Becker","sequence":"additional","affiliation":[{"name":"Department of 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