{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T14:06:32Z","timestamp":1767276392059,"version":"3.40.5"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,11,9]],"date-time":"2023-11-09T00:00:00Z","timestamp":1699488000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neuroimaging"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Purpose<\/jats:title><jats:p>Thalamic hypometabolism is a consistent finding in brain PET with F\u201018 fluorodeoxyglucose (FDG) in patients with neurofibromatosis type 1 (NF1). However, the pathophysiology of this metabolic alteration is unknown. We hypothesized that it might be secondary to disturbance of peripheral input to the thalamus by NF1\u2010characteristic peripheral nerve sheath tumors (PNSTs). To test this hypothesis, we investigated the relationship between thalamic FDG uptake and the number, volume, and localization of PNSTs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective study included 22 adult NF1 patients (41% women, 36.2\u00a0\u00b1\u00a013.0\u00a0years) referred to whole\u2010body FDG\u2010PET\/contrast\u2010enhanced CT for suspected malignant transformation of PNSTs and 22 sex\u2010 and age\u2010matched controls. Brain FDG uptake was scaled voxelwise to the individual median uptake in cerebellar gray matter. Bilateral mean and left\u2010right asymmetry of thalamic FDG uptake were determined using a left\u2010right symmetric anatomical thalamus mask. PNSTs were manually segmented in contrast\u2010enhanced CT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thalamic FDG uptake was reduced in NF1 patients by 2.0 standard deviations (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.0005) compared to controls. Left\u2010right asymmetry was increased by 1.3 standard deviations (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.013). Thalamic hypometabolism was higher in NF1 patients with \u22653 PNSTs than in patients with \u22642 PNSTs (2.6 vs. 1.6 standard deviations, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.032). The impact of the occurrence of paraspinal\/paravertebral PNSTs and of the mean PNST volume on thalamic FDG uptake did not reach statistical significance (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.098 and <jats:italic>p<\/jats:italic>\u00a0=\u00a0.189). Left\u2010right asymmetry of thalamic FDG uptake was not associated with left\u2010right asymmetry of PNST burden (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.658).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study provides first evidence of left\u2010right asymmetry of thalamic hypometabolism in NF1 and that it might be mediated by NF1\u2010associated peripheral tumors.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jon.13170","type":"journal-article","created":{"date-parts":[[2023,11,9]],"date-time":"2023-11-09T10:15:44Z","timestamp":1699524944000},"page":"138-144","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Asymmetry of thalamic hypometabolism on FDG\u2010PET\/CT in neurofibromatosis type 1: Association with peripheral tumor burden"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1549-6101","authenticated-orcid":false,"given":"Cansu","family":"\u00d6zden","sequence":"first","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology and Nuclear Medicine University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor\u2010Felix","family":"Mautner","sequence":"additional","affiliation":[{"name":"Department of Neurology University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Said","family":"Farschtschi","sequence":"additional","affiliation":[{"name":"Department of Neurology University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabel","family":"Molwitz","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology and Nuclear Medicine University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3032-2321","authenticated-orcid":false,"given":"Inka","family":"Ristow","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology and Nuclear Medicine University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Bannas","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology and Nuclear Medicine University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lennart","family":"Well","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology and Nuclear Medicine University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanne","family":"Klutmann","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology and Nuclear Medicine University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerhard","family":"Adam","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology and Nuclear Medicine University Medical Center Hamburg\u2010Eppendorf  Hamburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivayla","family":"Apostolova","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology and Nuclear Medicine University Medical Center Hamburg\u2010Eppendorf  Hamburg 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