{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T05:11:55Z","timestamp":1790053915599,"version":"4.0.1"},"reference-count":51,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T00:00:00Z","timestamp":1701043200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["KL2500\/8\u20101"],"award-info":[{"award-number":["KL2500\/8\u20101"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neuroimaging"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and purpose<\/jats:title><jats:p>Many studies have shown that exposure to life events can have a negative impact on mental health. Life events like the death of a spouse or the birth of a child pose a challenge and require temporal or permanent adjustments. Meta\u2010analyses on brain stress responses found bilateral anterior insula activation in response to acute stress. Fear conditioning is assumed a crucial mechanism for the development of anxiety disorders associated with increased activation in the bilateral amygdala. Empirical evidence is lacking regarding the relationship of exposure to recent life events and past childhood adversity with neural processing during fear conditioning.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In the present study, we analyzed data from 103 young, healthy participants. Multiple linear regressions were performed on functional magnetic resonance imaging activation during fear conditioning with the Life Events Scale for Students and the Childhood Trauma questionnaire included as covariates in two separate models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found a positive relationship between the number of life events in the last year and left amygdala activation to the conditioned stimulus. A second finding was a positive relationship between childhood adversity and right anterior insula response to the unconditioned stimulus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Many studies have shown increased amygdala activity after stressful life events. In addition, the anterior insula is activated during acute stress. The present study points to stressor\u2010induced increased salience processing during fear conditioning. We suggest that this could be a potential mechanism for resilience versus mental illness.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jon.13174","type":"journal-article","created":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T23:51:32Z","timestamp":1701129092000},"page":"217-223","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The impact of past childhood adversity and recent life events on neural responses during fear conditioning"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8639-8547","authenticated-orcid":false,"given":"Miriam","family":"Kampa","sequence":"first","affiliation":[{"name":"Department of Clinical Psychology and Psychotherapy University of Siegen  Siegen Germany"},{"name":"Bender Institute of Neuroimaging Justus Liebig University  Giessen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudolf","family":"Stark","sequence":"additional","affiliation":[{"name":"Bender Institute of Neuroimaging Justus Liebig University  Giessen Germany"},{"name":"Department of Psychotherapy and Systems Neuroscience Justus Liebig University Giessen  Giessen Germany"},{"name":"Center for Mind, Brain, and Behavior (CMBB) University of Marburg and Justus Liebig University Giessen  Giessen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2433-6652","authenticated-orcid":false,"given":"Tim","family":"Klucken","sequence":"additional","affiliation":[{"name":"Department of Clinical Psychology and Psychotherapy University of Siegen  Siegen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,11,27]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00127-017-1451-4"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/10615806.2015.1005078"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0213700"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1017\/S003329172000241X"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/1469-7610.00147"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0191-8869(96)00005-0"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5587-06.2007"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2021.01.001"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2015.06.059"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.5214\/ans.0972-7531.1017309"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1037\/h0069608"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/35077083"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1025048802629"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2011.04.023"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2007.07030504"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/2045-5380-2-9"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2016.06.009"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsycho.2019.107744"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/da.22353"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brat.2004.10.007"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsycho.2011.12.007"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2009.09030410"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2015.88"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhad205"},{"key":"e_1_2_6_26_1","first-page":"31","article-title":"General Health Questionnaire 28 (GHQ\u201028): teststatistische \u00dcberpr\u00fcfung einer deutschen Version in einer bev\u00f6lkerungsrepr\u00e4sentativen Stichprobe","volume":"52","author":"Klaiberg A","year":"2004","journal-title":"Z F\u00fcr Klin Psychol Psychiatr Psychother."},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291700021644"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0030-1253494"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1295495"},{"key":"e_1_2_6_30_1","unstructured":"BernsteinDP FinkL HandelsmanL FooteJ.Childhood Trauma Questionnaire. Accessed March 21 2023. Available at:https:\/\/doi.org\/10.1037\/t02080\u2010000"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2010.04.028"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.24218"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2017.10.043"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.10.018"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.162.7.1256"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.01.021"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2005.11.020"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2006.06.027"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2020.09.016"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.23681"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2017.03.016"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12888-017-1201-x"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2014.12.055"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2010.132"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0903183106"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0247036"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psym.2011.01.036"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ssmph.2019.100533"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13104-016-2278-x"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2022.04.018"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.10.065"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1080\/1047840X.2015.992677"}],"container-title":["Journal of Neuroimaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jon.13174","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,11]],"date-time":"2024-03-11T13:20:50Z","timestamp":1710163250000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jon.13174"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,27]]},"references-count":51,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["10.1111\/jon.13174"],"URL":"https:\/\/doi.org\/10.1111\/jon.13174","archive":["Portico"],"relation":{},"ISSN":["1051-2284","1552-6569"],"issn-type":[{"value":"1051-2284","type":"print"},{"value":"1552-6569","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,27]]},"assertion":[{"value":"2023-08-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}