{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T16:26:39Z","timestamp":1787934399207,"version":"build-2784847793"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,12,6]],"date-time":"2023-12-06T00:00:00Z","timestamp":1701820800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neuroimaging"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Purpose<\/jats:title><jats:p>Acute ischemic stroke due to large vessel occlusion (AIS\u2010LVO) is a major cause of functional dependence. Collateral status (CS) is an important determinant of functional outcomes. Pretreatment CT perfusion (CTP) parameters serve as reliable surrogates of CS. Penumbra Salvage Index (PSI) is another parameter predictive of functional outcomes in AIS\u2010LVO. The aim of this study is to assess the relationship of pretreatment CTP parameters with PSI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this prospectively collected, retrospectively reviewed multicenter analysis, inclusion criteria were as follows: (1) CT angiography confirmed middle cerebral artery (MCA) M1\u2010segment and proximal M2\u2010segment occlusion from 9\/1\/2017 to 9\/22\/2022; (2) diagnostic CTP; and (3) available diagnostic Magnetic resonance Imaging (MRI) diffusion\u2010weighted images. Pearson correlation analysis was performed to assess the association between cerebral blood volume (CBV) index and hypoperfusion intensity ratio (HIR) with PSI. <jats:italic>p<\/jats:italic> value \u2264.05 was considered statistically significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 131 patients (<jats:italic>n<\/jats:italic> = 86, M1 and <jats:italic>n<\/jats:italic> = 45, proximal M2 occlusion) met our inclusion criteria. CBV index showed a modest positive correlation with PSI (<jats:italic>r<\/jats:italic> = 0.34, <jats:italic>p<\/jats:italic>&lt;.001) in patients with proximal MCA occlusion. Similar trends were noted in subgroup analysis of patients with M1 occlusion, and proximal M2 occlusion. Whereas, HIR did not have a strong trend or correlation with PSI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>CBV index correlates with PSI, whereas HIR does not. Future studies are needed to expand our understanding of the adjunct role of CBV index with other similar pretreatment CTP\u2010based markers in clinical evaluation and decision\u2010making in patients with MCA occlusion.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jon.13178","type":"journal-article","created":{"date-parts":[[2023,12,7]],"date-time":"2023-12-07T21:37:17Z","timestamp":1701985037000},"page":"44-49","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Pretreatment CT perfusion collateral parameters correlate with penumbra salvage in middle cerebral artery occlusion"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7577-1887","authenticated-orcid":false,"given":"Dhairya A.","family":"Lakhani","sequence":"first","affiliation":[{"name":"Department of Radiology and Radiological Sciences Johns Hopkins University  Baltimore Maryland 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