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With conventional magnetic resonance imaging (MRI) suffering from various limitations, high\u2010resolution single\u2010shot T1 mapping has been proposed as a novel MRI technique in cSCS diagnosis. In this study, we investigated the effect of conservative and surgical treatment on spinal cord T1 relaxation times in cSCS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>T1\u2010mapping was performed in 54 patients with cSCS at 3 Tesla MRI at the maximum\u2010, above and below the stenosis. Subsequently, intraindividual T1\u2010differences (\u0394T1) intrastenosis were calculated. Twenty\u2010four patients received follow\u2010up scans after 6 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Surgically treated patients showed higher \u0394T1 at baseline (154.9 \u00b1 81.6\u00a0vs. 95.3 \u00b1 60.7), while absolute T1\u2010values within the stenosis were comparable between groups (863.7 \u00b1 89.3\u00a0milliseconds vs. 855.1 \u00b1 62.2\u00a0milliseconds). In surgically treated patients, \u0394T1 decreased inverse to stenosis severity. After 6 months, \u0394T1 significantly decreased in the surgical group (154.9 \u00b1 81.6\u00a0milliseconds to 85.7 \u00b1 108.9\u00a0milliseconds, <jats:italic>p<\/jats:italic> = .021) and remained unchanged in conservatively treated patients. Both groups showed clinical improvement at the 6\u2010month follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Baseline difference of T1 relaxation time (\u0394T1) might serve as a supporting marker for treatment decision and change of T1 relaxation time might reflect relief of spinal cord narrowing indicating regenerative processes. Quantitative T1\u2010mapping represents a promising additional imaging method to indicate a surgical treatment plan and to validate treatment success.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jon.13195","type":"journal-article","created":{"date-parts":[[2024,2,26]],"date-time":"2024-02-26T04:25:23Z","timestamp":1708921523000},"page":"329-338","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["T1 mapping in patients with cervical spinal canal stenosis with and without decompressive surgery: A longitudinal study"],"prefix":"10.1111","volume":"34","author":[{"given":"Meyer","family":"Stefanie","sequence":"first","affiliation":[{"name":"Department of Neurology University Medical Center G\u00f6ttingen  G\u00f6ttingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geiger","family":"Antonia","sequence":"additional","affiliation":[{"name":"Department of Neurology University Medical Center 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