{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:48:06Z","timestamp":1791895686333,"version":"4.3.4"},"reference-count":73,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,9,9]],"date-time":"2024-09-09T00:00:00Z","timestamp":1725840000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1R01NS134987\u201001"],"award-info":[{"award-number":["1R01NS134987\u201001"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neuroimaging"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Purpose<\/jats:title><jats:p>Neuropathic pain (NP) is a debilitating condition following spinal cord injury (SCI). The role of periaqueductal gray (PAG) in NP development following SCI remains underexplored. Using resting\u2010state functional MRI (rsfMRI), our study aimed to demonstrate the alterations in functional connectivity (FC) of PAG in NP following SCI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Ten SCI patients (SCI\u00a0+\u00a0NP, <jats:italic>n<\/jats:italic>\u00a0=\u00a07, and SCI\u00a0\u2212\u00a0NP, <jats:italic>n<\/jats:italic>\u00a0=\u00a03), alongside 10 healthy controls (HCs), were enrolled. rsfMRI was conducted followed by seed\u2010to\u2010voxel analysis using PAG as the seed region and then group\u2010based analysis comprising three groups (SCI\u00a0+\u00a0NP, SCI\u00a0\u2212\u00a0NP, and HC). Age and gender were considered as confounding variables.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared to HCs, SCI\u00a0+\u00a0NP demonstrated decreased FC between PAG and right insula, right frontal orbital cortex, right pallidum, dorsal raphe nucleus (DRN), red nuclei (RN), substantia nigra (SN), and ventral posterolateral (VPL) thalamic nuclei. Compared to SCI\u00a0\u2212\u00a0NP, SCI\u00a0+\u00a0NP demonstrated increased FC between PAG and posterior cingulate cortex (PCC), hippocampus, cerebellar vermis lobules IV and V, and thalamic structures (posterior and lateral pulvinar, the mediodorsal nuclei, and the ventral lateral nuclei). Additionally, decreased FC between the PAG and VPL, geniculate bodies, intralaminar nuclei of thalamus, DRN, RN, SN, and prefrontal cortex was observed in this comparison.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Altered FC between PAG and right anterior insula, VPL, DRN, RN, SN, cerebellar vermis lobules IV and V, frontal cortex, and PCC was associated with NP sequelae of SCI. Additionally, SCI was independently associated with decreased FC between PAG and right posterior insula, cerebellar lobules IV and V, and cerebellar vermis lobules III, IV, and V.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jon.13237","type":"journal-article","created":{"date-parts":[[2024,9,10]],"date-time":"2024-09-10T06:39:30Z","timestamp":1725950370000},"page":"704-719","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Periaqueductal gray connectivity in spinal cord injury\u2010induced neuropathic pain"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1387-3866","authenticated-orcid":false,"given":"Omid","family":"Shoraka","sequence":"first","affiliation":[{"name":"Department of Neurological Surgery, Vickie and Jack Farber Institute for Neuroscience Thomas Jefferson University  Philadelphia Pennsylvania 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