{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T02:09:15Z","timestamp":1792807755005,"version":"4.5.0"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T00:00:00Z","timestamp":1736726400000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004836","name":"Danmarks Frie Forskningsfond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004836","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neuroimaging"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Purpose<\/jats:title>\n                    <jats:p>This study aims to investigate the longitudinal changes in translocator protein (TSPO) following stroke in different brain regions and potential associations with chronic brain infarction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Twelve patients underwent SPECT using the TSPO tracer 6\u2010Chloro\u20102\u2010(4\u02b9\u2010123I\u2010Iodophenyl)\u20103\u2010(\n                      <jats:italic>N<\/jats:italic>\n                      ,\n                      <jats:italic>N<\/jats:italic>\n                      \u2010Diethyl)\u2010Imidazo[1,2\u2010a]Pyridine\u20103\u2010Acetamide, as well as structural MRI, at 10, 41, and 128\u00a0days (median) after ischemic infarction in the middle cerebral artery. TSPO expression was measured in lesional (MRI lesion and SPECT lesion), connected (pons and ipsilesional thalamus), and nonconnected (ipsilesional cerebellum and contralesional occipital cortex) regions. Correlations were explored between the volume of chronic infarction and TSPO expression in nonconnected regions of interest (ROIs) at 128\u00a0days\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Throughout the study period, TSPO levels decreased by 24%\u201333% in lesional ROIs, while levels increased in connected ROIs by 35%\u201369% and in nonconnected ROIs by 53%\u201377%. At 128\u00a0days poststroke, TSPO expression in ipsilesional cerebellum positively correlated with chronic infarction volume (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.001,\n                      <jats:italic>r<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u00a0=\u00a00.78).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study expands the current knowledge of spatial and temporal TSPO expression in humans by quantifying TSPO changes in lesional, connected, and nonconnected brain regions at three time points after cerebral infarction as well as correlating late\u2010stage TSPO upregulation and chronic infarction volume.<\/jats:p>\n                    <jats:p>[Correction added on January 29, 2025, after first online publication: The p and r2 values in the results section of the abstract have been corrected in this version].<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jon.70002","type":"journal-article","created":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T06:21:36Z","timestamp":1736749296000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Poststroke Translocator Protein Expression Dynamics and Correlations to Chronic Infarction: A\n                    <sup>[123I]<\/sup>\n                    \u2010CLINDE\u2010SPECT Study"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5246-390X","authenticated-orcid":false,"given":"Per","family":"Jensen","sequence":"first","affiliation":[{"name":"Neurobiology Research Unit Rigshospitalet, University of Copenhagen  Copenhagen Denmark"},{"name":"Epilepsy Clinic Rigshospitalet, University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brice","family":"Ozenne","sequence":"additional","affiliation":[{"name":"Neurobiology Research Unit Rigshospitalet, University of Copenhagen  Copenhagen Denmark"},{"name":"Department of Public Health, Section of Biostatistics University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per","family":"Meden","sequence":"additional","affiliation":[{"name":"Department of Neurology Bispebjerg Hospital, University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Feng","sequence":"additional","affiliation":[{"name":"Neurobiology Research Unit Rigshospitalet, University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerda","family":"Thomsen","sequence":"additional","affiliation":[{"name":"Neurobiology Research Unit Rigshospitalet, University of Copenhagen  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