{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T09:03:12Z","timestamp":1791450192307,"version":"4.3.3"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,15]],"date-time":"2025-01-15T00:00:00Z","timestamp":1736899200000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000890","name":"National Multiple Sclerosis Society","doi-asserted-by":"publisher","award":["FG\u20102208\u201040289"],"award-info":[{"award-number":["FG\u20102208\u201040289"]}],"id":[{"id":"10.13039\/100000890","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neuroimaging"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Purpose<\/jats:title>\n                    <jats:p>MRI is crucial for multiple sclerosis (MS), but the relative value of portable ultra\u2010low field MRI (pULF\u2010MRI), a technology that holds promise for extending access to MRI, is unknown. We assessed white matter lesion (WML) detection on pULF\u2010MRI compared to high\u2010field MRI (HF\u2010MRI), focusing on blinded assessments, assessor self\u2010training, and multiplanar acquisitions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Fifty\u2010five adults with MS underwent pULF\u2010MRI following their HF\u2010MRI. Two neuroradiologists independently assessed pULF\u2010MRI images in an evaluation process, including initial assessment blinded to HF\u2010MRI, self\u2010training with reference to HF\u2010MRI and evaluation of 20 cases with additional T2\u2010fluid\u2010attenuated inversion recovery in an additional plane. A third rater conducted cross\u2010referenced analysis with HF\u2010MRI data to determine true\u2010positive lesions, false\u2010positive areas, and case\u2010level sensitivity and positive predictive value.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The mean age of participants was 50 years (standard deviation: 11; 74% women). Initially, Rater 2 marked more false\u2010positive areas than Rater 1 (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.003). After self\u2010training, both raters embraced a conservative approach, with Rater 2 marking fewer false\u2010positive areas (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.01). Both raters maintained 100% case\u2010level sensitivity and positive predictive value for detecting at least one WML, particularly in periventricular areas. Multiplanar acquisitions reduced both false\u2010positive areas and true\u2010positive lesions. True\u2010positive lesions and false\u2010positive areas had similar contrast\u2010to\u2010noise ratios in the juxtacortical region (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.73) but not in periventricular, deep parenchymal regions (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.004,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>With adequate training, radiological interpretation of pULF\u2010MRI has high sensitivity and positive predictive value for MS lesions but should be approached conservatively. These results suggest utility for patient triage, potentially reducing diagnostic delay, and screening high\u2010risk individuals.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jon.70005","type":"journal-article","created":{"date-parts":[[2025,1,15]],"date-time":"2025-01-15T23:24:41Z","timestamp":1736983481000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["High\u2010Field\u2010Blinded Assessment of Portable Ultra\u2010Low\u2010Field Brain MRI for Multiple Sclerosis"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3716-2196","authenticated-orcid":false,"given":"Serhat V.","family":"Okar","sequence":"first","affiliation":[{"name":"Translational Neuroradiology Section, National Institute of Neurological Disorders and Stroke National Institutes of Health  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Govind","family":"Nair","sequence":"additional","affiliation":[{"name":"qMRI Core Facility National Institute of Neurological Disorders and Stroke National Institutes of Health  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karan D.","family":"Kawatra","sequence":"additional","affiliation":[{"name":"Neuroimmunology Clinic, National Institute of Neurological Disorders and Stroke National Institutes of Health  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley A.","family":"Thommana","sequence":"additional","affiliation":[{"name":"Translational Neuroradiology Section, National Institute of Neurological Disorders and Stroke National Institutes of Health  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corinne A.","family":"Donnay","sequence":"additional","affiliation":[{"name":"Translational Neuroradiology Section, National Institute of Neurological Disorders and Stroke National Institutes of Health  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda I.","family":"Gait\u00e1n","sequence":"additional","affiliation":[{"name":"Translational Neuroradiology Section, National Institute of Neurological Disorders and Stroke National Institutes of Health  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel M.","family":"Stein","sequence":"additional","affiliation":[{"name":"Center for Neuroengineering and Therapeutics University of Pennsylvania  Philadelphia Pennsylvania USA"},{"name":"Department of Radiology Perelman School of Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel S.","family":"Reich","sequence":"additional","affiliation":[{"name":"Translational Neuroradiology Section, National Institute of Neurological Disorders and Stroke National Institutes of Health  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,15]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(17)30299-5"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(21)00095-8"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(17)30470-2"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.26942"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000207074"},{"key":"e_1_2_8_7_1","volume-title":"Science","author":"Cho 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