{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T17:23:44Z","timestamp":1789579424735,"version":"build-2803163510"},"reference-count":57,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T00:00:00Z","timestamp":1736467200000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100006364","name":"Institut National Du Cancer","doi-asserted-by":"publisher","award":["NCT04324450 (MR ROBOT project #2017\u2010120"],"award-info":[{"award-number":["NCT04324450 (MR ROBOT project #2017\u2010120"]}],"id":[{"id":"10.13039\/501100006364","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006364","name":"Institut National Du Cancer","doi-asserted-by":"publisher","award":["pediatric"],"award-info":[{"award-number":["pediatric"]}],"id":[{"id":"10.13039\/501100006364","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neuroimaging"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Purpose<\/jats:title>\n                    <jats:p>Working memory, a primary cognitive domain, is often impaired in pediatric brain tumor survivors, affecting their attention and processing speed. This study investigated the long\u2010term effects of treatments, including surgery, radiotherapy (RT), and chemotherapy (CT), on working memory tracts in children with posterior fossa tumors (PFTs) using resting\u2010state functional MRI (rs\u2010fMRI) and diffusion MRI tractography.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study included 16 medulloblastoma (MB) survivors treated with postoperative RT and CT, 14 pilocytic astrocytoma (PA) survivors treated with surgery alone, and 16 healthy controls from the Imaging Memory after Pediatric Cancer in children, adolescents, and young adults study (NCT04324450). Working memory tracts were identified by combining seed masks from rs\u2010fMRI maps and whole\u2010brain tractography from diffusion MRI. Connectivity alterations were assessed qualitatively and quantitatively, alongside neuropsychological evaluations and correlations with behavioral outcomes and mean supratentorial dose.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Compared to controls, MB survivors exhibited significant impairments in the working memory network, including reductions in tract volume (TV), fiber density, fiber cross\u2010section (FC), mean streamline length (MLS), and fractional anisotropy (FA) (all\n                      <jats:italic>p<\/jats:italic>\n                      = 0.04). Lower working memory scores were correlated with reduced TV and FA in MB survivors. Higher mean supratentorial doses were associated with lower TV, FC, and FA values across multiple tracts, particularly in the arcuate and superior longitudinal fasciculi.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Tractography\u2010derived features highlighted white matter damage as a biomarker of treatment\u2010related neurotoxicity in PFTs survivors. These findings underscore the detrimental impact of RT and CT on working memory networks and emphasize the importance of preserving cognitive function during treatment planning.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jon.70007","type":"journal-article","created":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T03:06:50Z","timestamp":1736478410000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Impact of Pediatric Posterior Fossa Tumor Treatments on Working Memory Tracts Using Resting\u2010State fMRI and Tractography"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9107-3923","authenticated-orcid":false,"given":"Abir Troudi","family":"Habibi","sequence":"first","affiliation":[{"name":"University of Tunis El Manar Higher Institute of Medical Technologies of Tunis, Research Laboratory of Biophysics and Medical Technologies LR13ES07  Tunis Tunisia"},{"name":"Toulouse NeuroImaging Center (ToNIC), INSERM University of Toulouse Paul Sabatier  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ines Ben","family":"Alaya","sequence":"additional","affiliation":[{"name":"University of Tunis El Manar Higher Institute of Medical Technologies of Tunis, Research Laboratory of Biophysics and Medical Technologies LR13ES07  Tunis Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatima","family":"Tensaouti","sequence":"additional","affiliation":[{"name":"Toulouse NeuroImaging Center (ToNIC), INSERM University of Toulouse Paul Sabatier  Toulouse France"},{"name":"Radiation Oncology Department Claudius Regaud Institute, Toulouse University Cancer Institute, Oncopole  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elo\u00efse","family":"Baudou","sequence":"additional","affiliation":[{"name":"Toulouse NeuroImaging Center (ToNIC), INSERM University of Toulouse Paul Sabatier  Toulouse France"},{"name":"Pediatric Neurology Department Children's Hospital Toulouse University Hospital  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Germain","family":"Arribarat","sequence":"additional","affiliation":[{"name":"Toulouse NeuroImaging Center (ToNIC), INSERM University of Toulouse Paul Sabatier  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Pollidoro","sequence":"additional","affiliation":[{"name":"Toulouse NeuroImaging Center (ToNIC), INSERM University of Toulouse Paul Sabatier  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrice","family":"P\u00e9ran","sequence":"additional","affiliation":[{"name":"Toulouse NeuroImaging Center (ToNIC), INSERM University of Toulouse Paul Sabatier  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves","family":"Chaix","sequence":"additional","affiliation":[{"name":"Toulouse NeuroImaging Center (ToNIC), INSERM University of Toulouse Paul Sabatier  Toulouse France"},{"name":"Pediatric Neurology Department Children's Hospital Toulouse University Hospital  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salam","family":"Labidi","sequence":"additional","affiliation":[{"name":"University of Tunis El Manar Higher Institute of Medical Technologies of Tunis, Research Laboratory of Biophysics and Medical Technologies LR13ES07  Tunis Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Laprie","sequence":"additional","affiliation":[{"name":"Toulouse NeuroImaging Center (ToNIC), INSERM University of Toulouse Paul Sabatier  Toulouse France"},{"name":"Radiation Oncology Department Claudius Regaud Institute, Toulouse University Cancer Institute, Oncopole  Toulouse France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2022.05.022"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurad.2019.01.093"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1364-6613(03)00197-9"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-psych-010814-015031"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh622"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2009.02.054"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1017\/S135561771300129X"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1215\/15228517-2006-002"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00066-022-01905-6"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2018.09.005"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.24539"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-020-02181-9"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2018.01055"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2018.05.044"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.16.9403"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.25305"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clon.2023.09.015"},{"key":"e_1_2_7_19_1","unstructured":"K.TerriotandR.Ozenne.\u201cApproche Neuropsychologique des Apprentissages chez \u201d L'\u00e9chelle d'intelligence de Wechsler pour enfants 5e \u00e9dition (WISC\u2010V) accessed November 15 2024 https:\/\/www.researchgate.net\/profile\/Katia\u2010Terriot\/publication\/282233542_Wechsler_intelligence_scale_for_children_v_version_WISC\u2010V\/links\/572901f408aef5d48d2c8f79\/Wechsler\u2010intelligence\u2010scale\u2010for\u2010children\u2010v\u2010version\u2010WISC\u2010V.pdf."},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.14375\/NP.9782804700164"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctro.2021.10.006"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2024.110599"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1089\/brain.2012.0073"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0073021"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-36480-8_60"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-46720-7_24"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2016.00027"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2015.05.017"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.24912"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.52294\/ApertureNeuro.2022.2.NEOD9565"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2016.09.029"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2517-6161.1995.tb02031.x"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.27924"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0131744"},{"key":"e_1_2_7_35_1","first-page":"1","article-title":"Abnormalities of Structural Brain Connectivity in Pediatric Brain Tumor Survivors","volume":"24","author":"Oyefiade A.","year":"2022","journal-title":"Neuro\u2010Oncology Advances"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(90)90264-K"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11355"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.02.4505"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2022.05.006"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.20.02315"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.03.065"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2017.09.010"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awg195"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnimg.2022.845609"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh685"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2007.02.012"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/ca.23914"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(85)80343-7"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1080\/09297049.2016.1183608"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617712000793"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2017.04.006"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2007.08.020"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2016.07.010"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djy009"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1080\/0284186X.2019.1571279"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-35817-4_11"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clon.2024.07.008"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2023.110073"}],"container-title":["Journal of Neuroimaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jon.70007","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jon.70007","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jon.70007","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T08:23:02Z","timestamp":1773044582000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jon.70007"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":57,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1111\/jon.70007"],"URL":"https:\/\/doi.org\/10.1111\/jon.70007","archive":["Portico"],"relation":{},"ISSN":["1051-2284","1552-6569"],"issn-type":[{"value":"1051-2284","type":"print"},{"value":"1552-6569","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2024-09-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70007"}}