{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T16:02:35Z","timestamp":1790179355221,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T00:00:00Z","timestamp":1736726400000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neuroimaging"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Purpose<\/jats:title>\n                    <jats:p>Endovascular thrombectomy (EVT) is the standard for acute ischemic stroke from large vessel occlusion, but post\u2010EVT functional independence varies. Brain atrophy, linked to higher cerebrospinal fluid volume (CSFV), may affect outcomes. Baseline CSFV could predict EVT benefit by assessing brain health. We aimed to quantify total CSFV from clinical T1\u2010weighted (w) magnetic resonance imaging (MRI) to assess global brain atrophy and its association with functional outcomes following successful EVT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We performed a retrospective analysis of patients achieving thrombolysis\u2010in\u2010cerebral\u2010infarction \u22652b revascularization via prospectively maintained single\u2010institution stroke thrombectomy registry (\n                      <jats:italic>n<\/jats:italic>\n                      = 432) between 2015 and 2021. We included 214 patients (mean age 67.5\u00a0\u00b1\u00a014.6, 49% female) with acceptable quality MRI within 14\u00a0days of EVT and available modified Rankin\u2010scale (mRS) at 90\u00a0days post EVT. Clinical T1w images were transformed into high\u2010resolution images using the convolutional neural\u2010network SynthSR. FreeSurfer software was then used to estimate total cranial CSFV. To correct for head size, percentage of CSFV to intracranial volume was used.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Baseline CSFV% significantly predicted 90\u2010day mRS in an ordinal regression model adjusted for baseline mRS (\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      &lt;\u00a00.001). Further modeling was performed to account for age, sex, 24\u2010h National\u2010Institutes\u2010Health\u2010Stroke\u2010Scale (NIHSS), smoking history, prior stroke, hypertension, congestive heart failure, hemoglobin\u2010A1c, atrial fibrillation, and Alberta\u2010Stroke\u2010Program\u2010Early\u2010CT\u2010Score (ASPECTS). Total CSFV% remained an independent predictor of 90\u2010day mRS (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.012). CSFV% did not significantly predict the occurrence of any type of hemorrhagic transformation in a logistic regression model.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Increased CSFV% correlates with poorer functional outcomes post EVT. Total CSFV% may serve as a useful imaging biomarker for clinicians determining patient prognostication prior to EVT.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jon.70013","type":"journal-article","created":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T06:00:04Z","timestamp":1736748004000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Utilizing Quantitative Analysis of CSF Volume from Clinical T1\u2010Weighted MRI to Predict Thrombectomy Outcomes"],"prefix":"10.1111","volume":"35","author":[{"given":"Mohammad I.","family":"Kawas","sequence":"first","affiliation":[{"name":"Department of Radiology Wake Forest University School of Medicine  Winston\u2010Salem North Carolina USA"},{"name":"Department of Physiology and Biochemistry (M.I.K.) Faculty of Medicine University of Jordan  Amman Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad","family":"Shamulzai","sequence":"additional","affiliation":[{"name":"Department of Neurology North Shore University Hospital Northwell Health  Manhasset New York USA"},{"name":"Department of Neurosurgery Wake Forest University School of Medicine  Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6150-8671","authenticated-orcid":false,"given":"Kyle M.","family":"Atcheson","sequence":"additional","affiliation":[{"name":"Department of Radiology Wake Forest University School of Medicine  Winston\u2010Salem North Carolina USA"},{"name":"Department of Radiology McGaw Medical Center at Northwestern University  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1052-6826","authenticated-orcid":false,"given":"Alex C.","family":"Horn","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Wake Forest University School of Medicine  Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renate","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Wake Forest University School of Medicine  Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol","family":"Kittel","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Wake Forest University School of Medicine  Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Curry","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Wake Forest University School of Medicine  Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan","family":"Lipford","sequence":"additional","affiliation":[{"name":"Department of Radiology Wake Forest University School of Medicine  Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeongchul","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Radiology Wake Forest University School of Medicine  Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiran K.","family":"Solingapuram Sai","sequence":"additional","affiliation":[{"name":"Department of Radiology Wake Forest University School of Medicine  Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacey Q.","family":"Wolfe","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Wake Forest University School of Medicine  Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher T.","family":"Whitlow","sequence":"additional","affiliation":[{"name":"Department of Radiology Wake Forest University School of Medicine  Winston\u2010Salem North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,13]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)00163-X"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2019.8286"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2022.1056532"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-018-0408-5"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.119.027120"},{"key":"e_1_2_7_7_1","article-title":"Brain Atrophy and Endovascular Treatment Effect in Acute Ischemic Stroke: A Secondary Analysis of the MR CLEAN Trial","volume":"17","author":"Luijten S. 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