{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T09:17:36Z","timestamp":1773047856931,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,12]],"date-time":"2025-01-12T00:00:00Z","timestamp":1736640000000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neuroimaging"],"published-print":{"date-parts":[[2025,1]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background and Purpose<\/jats:title>\n We investigated the relationship between serotonergic and dopaminergic specific binding transporter ratios (SBRs) over 4\u00a0years in Parkinson's disease (PD) patients. We assessed serotonergic innervation's potential compensatory role for dopaminergic denervation, association with PD symptoms, and involvement in the development of levodopa\u2010induced dyskinesia (LID).<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n SBRs of the midbrain and striatum were evaluated from [I\u2010123]\n N<\/jats:italic>\n \u2010\u03c9\u2010fluoropropyl\u20102\u03b2\u2010carbomethoxy\u20103\u03b2\u2010(4\u2010iodophenyl)nortropane SPECT images at baseline and after 4\u00a0years. Correlations between SBRs and PD symptoms were analyzed, alongside interval changes.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Study included 177 PD patients (110 males, 67 females; mean age 61.0\u00a0\u00b1\u00a09.0\u00a0years). Significant worsening was observed in Hoehn and Yahr staging and Movement Disorder Society\u2010Unified Parkinson's Disease Rating Scale (MDS\u2010UPDRS) Part II and III scores over 4\u00a0years (\n p<\/jats:italic>\n \u00a0<\u00a00.05,\n p<\/jats:italic>\n \u00a0<\u00a00.001, and\n p<\/jats:italic>\n \u00a0<\u00a00.001, respectively). SBRs of the caudate, putamen, and midbrain declined significantly (\n p<\/jats:italic>\n \u00a0<\u00a00.001). Midbrain and striatal SBRs correlated significantly at both baseline and 4\u2010year follow\u2010up (\n p<\/jats:italic>\n \u00a0<\u00a00.0001). Striatal SBRs correlated significantly with MDS\u2010UPDRS II and III scores at both time points, while midbrain SBRs correlated with changes in MDS\u2010UPDRS III scores over the 4\u00a0years (\n p<\/jats:italic>\n \u00a0<\u00a00.01). Putamen and midbrain SBRs at 4\u00a0years were significantly lower in patients who developed LID compared to those who did not (\n p<\/jats:italic>\n \u00a0<\u00a00.05).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n The study demonstrates correlations between midbrain and putamen SBRs and MDS\u2010UPDRS scores over 4\u00a0years in PD patients. Midbrain serotonin dysfunction may contribute to the development of LID.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jon.70014","type":"journal-article","created":{"date-parts":[[2025,1,12]],"date-time":"2025-01-12T23:28:26Z","timestamp":1736724506000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Longitudinal Serotonergic and Dopaminergic Binding: Impact on Parkinson's Disease Progression and Levodopa Dyskinesia"],"prefix":"10.1111","volume":"35","author":[{"given":"Eun Hye","family":"Jeong","sequence":"first","affiliation":[{"name":"Department of Neurology Bundang Jesaeng General Hospital Seongnam\u2010si Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae Yong","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Neurology Bundang Jesaeng General Hospital Seongnam\u2010si Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7985-1358","authenticated-orcid":false,"given":"Yoo Sung","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine Seoul National University Bundang Hospital Seongnam\u2010si Republic of Korea"},{"name":"College of Medicine Seoul National University Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,1,12]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/bmb\/ldn013"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(73)90175-5"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-009-5240-1"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2008.02056.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/PL00007758"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2020.07.008"},{"key":"e_1_2_7_8_1","first-page":"870","article-title":"Serotonin Transporters in the Midbrain of Parkinson's Disease Patients: A Study With 123I\u2010Beta\u2010CIT SPECT","volume":"44","author":"Kim S. 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S.","year":"2008","journal-title":"Nuclear Medicine and Molecular Imaging"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awx376"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2019.00471"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.63.4.584"},{"key":"e_1_2_7_18_1","first-page":"1694","article-title":"Loss of Dopamine Transporter Binding in Parkinson's Disease Follows a Single Exponential Rather Than Linear Decline","volume":"45","author":"Schwarz J.","year":"2004","journal-title":"Journal of Nuclear Medicine"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2022.976101"}],"container-title":["Journal of Neuroimaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jon.70014","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jon.70014","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jon.70014","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T08:21:33Z","timestamp":1773044493000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jon.70014"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1111\/jon.70014"],"URL":"https:\/\/doi.org\/10.1111\/jon.70014","archive":["Portico"],"relation":{},"ISSN":["1051-2284","1552-6569"],"issn-type":[{"value":"1051-2284","type":"print"},{"value":"1552-6569","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2024-10-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70014"}}