{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,7]],"date-time":"2026-06-07T04:28:14Z","timestamp":1780806494553,"version":"3.54.1"},"reference-count":49,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T00:00:00Z","timestamp":1740355200000},"content-version":"vor","delay-in-days":54,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RF1 AG075717 F32AG082458"],"award-info":[{"award-number":["RF1 AG075717 F32AG082458"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neuroimaging"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Purpose<\/jats:title>\n                    <jats:p>This study aims to assess the potential of ultrashort echo time imaging\u2010based magnetization transfer ratio (UTE\u2010MTR) in detecting demyelination in mice with mild traumatic brain injury (mTBI) caused by an open\u2010field low\u2010intensity blast (LIB) injury model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This study included 30 male C57BL\/6 mice, approximately 8 weeks old, sourced from Jackson Laboratories in Bar Harbor, ME, and conducted under institutional guidelines. The mice were divided into the mTBI group (\n                      <jats:italic>n<\/jats:italic>\n                      = 15) and the sham control group (\n                      <jats:italic>n<\/jats:italic>\n                      = 15). All animal experiments followed the approved protocols for the Care and Use of Laboratory Animals and Animal Research. The mTBI group underwent the open\u2010field LIB injury. Behavioral tests were conducted to assess motor activity and anxiety\u2010like responses. UTE\u2010MT imaging was performed using a 3 Tesla Bruker system to measure UTE\u2010MTR from two UTE\u2010MT datasets with saturation powers of 1500\u00b0 and 500\u00b0, and two frequency offsets of 2 and 50\u00a0kHz, respectively. Luxol fast blue (LFB) staining was performed to evaluate myelin content. The mean UTE\u2010MTR values for regions of interest centered at the medial section of the corpus callosum were computed. The behavioral tests, LFB myelin staining, and UTE\u2010MTR values were compared between the two groups using the independent\n                      <jats:italic>t<\/jats:italic>\n                      \u2010test.\n                      <jats:italic>p<\/jats:italic>\n                      values &lt;0.05 were considered significant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The mTBI mice demonstrated decreased motor activity and increased anxiety\u2010like response over sham controls. The mTBI mice also showed significantly lower UTE\u2010MTR values (0.399\u00b10.007\u00a0vs. 0.393\u00b10.005;\n                      <jats:italic>p<\/jats:italic>\n                      &lt;0.05) and reduced LFB myelin staining (0.848\u00b10.324\u00a0vs. 1.145\u00b10.260;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.048) over sham controls.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The significantly lower UTE\u2010MTR values in the corpus callosum of mTBI mice are consistent with reduced LFB myelin staining, indicating that UTE\u2010MTR can detect myelin loss and associated alterations in motor and anxiety domains post\u2010LIB exposure.<\/jats:p>\n                  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