{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:28:30Z","timestamp":1753878510508,"version":"3.41.2"},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T00:00:00Z","timestamp":1744070400000},"content-version":"vor","delay-in-days":38,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neuroimaging"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background and Purpose<\/jats:title><jats:p>Temporal lobe epilepsy is the most common form of focal epilepsy. MR\u2010guided laser interstitial thermal therapy (LITT) of the amygdalohippocampal complex has become an established therapy option in case of drug resistance. Long\u2010term anatomic network effects on the brain due to deafferentiation have not yet been evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We analyzed brain volumes of 11 patients with temporal lobe epilepsy before and 1\u2010year after hippocampal LITT with FastSurfer segmenting T1\u2010weighted data. Additionally, we performed visual ratings and measurements.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 11 patients with temporal lobe epilepsy (7 left\u2010sided, 4 right\u2010sided) were included (5 females); the mean age years (\u00b1standard deviation) at surgery was 41.5 (\u00b118.4) years. The mean postoperative defect size was 1427 (\u00b1517)\u00a0mm<jats:sup>3<\/jats:sup>. Volumetry as well as visual ratings found a progressive volume loss after left\u2010sided surgery in the ipsilateral temporal lobe, the contralateral (right) part of the thalamus, and especially contralateral (right) fusiform cortex. These changes could not be detected for right\u2010sided surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A (partial) ablation of the left (dominant) hippocampus appears to exert long\u2010term effects on the right thalamus and right\u2010sided temporal cortices. However, we could not observe this effect in the reverse direction. Volumetric studies for larger cohorts should be conducted to investigate these findings.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jon.70039","type":"journal-article","created":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T13:37:46Z","timestamp":1744119466000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Brain Volume Loss After Stereotactic Laser Interstitial Thermal Therapy in Patients With Temporal Lobe Epilepsy"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2147-9797","authenticated-orcid":false,"given":"Sebastian Johannes","family":"M\u00fcller","sequence":"first","affiliation":[{"name":"Clinic for Neuroradiology Otto\u2010Von\u2010Guericke\u2010University Magdeburg  Magdeburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eya","family":"Khadhraoui","sequence":"additional","affiliation":[{"name":"Clinic for Neuroradiology Otto\u2010Von\u2010Guericke\u2010University Magdeburg  Magdeburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olga","family":"Kukhlenko","sequence":"additional","affiliation":[{"name":"Clinic for Neurology Otto\u2010Von\u2010Guericke\u2010University Magdeburg  Magdeburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes","family":"Schwarzer","sequence":"additional","affiliation":[{"name":"Clinic for Neuroradiology Otto\u2010Von\u2010Guericke\u2010University Magdeburg  Magdeburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00fcrgen","family":"Voges","sequence":"additional","affiliation":[{"name":"Clinic for Stereotactic Neurosurgery Otto\u2010Von\u2010Guericke\u2010University Magdeburg  Magdeburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I. 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