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This meta\u2010analysis utilized Seed\u2010based d Mapping to assess variations in amplitude of low\u2010frequency fluctuations (ALFF) and fractional amplitude of low\u2010frequency fluctuations (fALFF). The aim was to identify common brain regions with altered spontaneous brain activity in migraine patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A systematic search was conducted in PubMed, Web of Science, and Embase for studies published up to August 2023, comparing spontaneous low\u2010frequency brain activity between migraine patients and healthy controls (HCs). Jackknife sensitivity, heterogeneity, publication bias, and meta\u2010regression analyses were performed to ensure the robustness and reliability of our findings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nine studies, including 708 migraine patients and HCs, were included in the analysis. Applying a highly conservative family\u2010wise error rate correction, no significant findings were observed. However, when a less conservative threshold was used, migraine patients exhibited increased ALFF\/fALFF in the left anterior thalamus and the corticospinal tract but showed decreased values in the right middle frontal gyrus. Jackknife sensitivity analysis confirmed the reproducibility of these results, while heterogeneity analysis revealed significant variability across studies, likely due to differences in study design and patient populations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This meta\u2010analysis provides a comprehensive synthesis of neuroimaging evidence, linking migraine to abnormal spontaneous brain activity in regions associated with pain processing and nociceptive emotional modulation. These findings enhance our understanding of migraine pathophysiology and highlight potential targets for neuromodulation therapies, offering new directions for future research and clinical interventions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jon.70043","type":"journal-article","created":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T04:09:30Z","timestamp":1748318970000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Aberrant Spontaneous Low\u2010Frequency Brain Activity in Migraine: A Meta\u2010Analysis of Resting\u2010State fMRI Studies"],"prefix":"10.1111","volume":"35","author":[{"given":"Qiuyi","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Acupuncture and Moxibustion Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing Key Laboratory of Acupuncture Neuromodulation  Beijing 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