{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T04:11:36Z","timestamp":1787890296655,"version":"build-2784847793"},"reference-count":16,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,4,26]],"date-time":"2025-04-26T00:00:00Z","timestamp":1745625600000},"content-version":"vor","delay-in-days":56,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neuroimaging"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background and Purpose<\/jats:title><jats:p>The superiority of achieving modified Treatment in Cerebral Ischemia (mTICI) from multiple passes versus mTICI 2b from a single pass remains uncertain. We aimed to assess whether additional passes in M1 occlusion patients with a first\u2010pass mTICI 2b score improved clinical and functional outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We analyzed Registry Combined vs. Single Thrombectomy Techniques registry data of consecutive M1\u2010occlusion patients, comparing outcomes of those with mTICI 2b\u2010stopped after the first pass versus continued mechanical thrombectomy (MT) to improve angiographic results (mTICI 2b or mTICI 2c\/3). We compared demographic, clinical, angiographic, and clinical outcome data (National Institute of Health Stroke Scale [NIHSS] at 24\u00a0h and modified Rankin Scale at 3 months).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients with first\u2010pass mTICI 2b had lower NIHSS scores at admission, fewer left\u2010side occlusions, and longer last\u2010seen\u2010well times. Endovascular techniques and time from groin puncture to revascularization were similar across groups. Patients with final mTICI 2c\/3 had the highest distal embolism rates in a new territory (0% for mTICI2b\u2010stopped vs. 3% for final mTICI2b\u2010continued; 7.7% for final mTICI2c\/3; p = 0.02). The groups had similar rates of death, symptomatic intracranial hemorrhage, same\u2010area distal embolism, other MT\u2010related complications, NIHSS at 24\u00a0h, NIHSS change from admission to 24\u00a0h, and same\u2010territory distal embolism.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Achieving mTICI 2b after the first pass in M1\u2010occlusion patients proved relevant. These patients had comparable clinical and functional outcomes and a lower risk of new territory distal embolisms compared to those with final mTICI 2c\/3 scores.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jon.70047","type":"journal-article","created":{"date-parts":[[2025,4,26]],"date-time":"2025-04-26T07:03:12Z","timestamp":1745650992000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Modified Treatment in Brain Ischemia 2b Stopped or Continued After First\u2010Pass Mechanical Thrombectomy for M1 Occlusions"],"prefix":"10.1111","volume":"35","author":[{"given":"Juan Ignacio","family":"Garc\u00eda\u2010Garc\u00eda","sequence":"first","affiliation":[{"name":"Neuroradiology Hospital Universitari de Bellvitge  Barcelona 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