{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T19:41:53Z","timestamp":1792093313854,"version":"4.4.0"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T00:00:00Z","timestamp":1748304000000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neuroimaging"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background and Purpose<\/jats:title><jats:p>Intracranial hypotension (IH) results from cerebrospinal fluid (CSF) leakage from the dural sac, occurring spontaneously or iatrogenically (e.g., post\u2010lumbar puncture), and may cause a wide range of symptoms with significant functional impairment. Accurate detection of the epidural CSF lamella is key to diagnosis. This study evaluated the diagnostic value of intravenous contrast\u2010enhanced MRI using heavily T2\u2010weighted FLAIR (HT2\u2010FLAIR) spine imaging compared to nonenhanced MR myelography at 3\u00a0Tesla.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Ten consecutive patients with IH symptoms were prospectively examined using HT2\u2010FLAIR imaging of the spine before and up to 3\u00a0h after gadolinium\u2010based contrast agent administration, alongside noncontrast MR myelography. Two readers assessed the conspicuity of the CSF lamella on contrast\u2010enhanced HT2\u2010FLAIR (ceHT2\u2010FLAIR) using a score from \u22122 to +2 and evaluated additional diagnostic benefit.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A CSF lamella was seen in eight of 10 patients as a strongly enhancing band on ceHT2\u2010FLAIR. In one case, the lamella was visible exclusively on ceHT2\u2010FLAIR (conspicuity score [CS]\u00a0=\u00a02, <jats:italic>n<\/jats:italic>\u00a0=\u00a01) and was more conspicuous in three cases (CS\u00a0=\u00a01, <jats:italic>n<\/jats:italic>\u00a0=\u00a03). Six cases showed equal conspicuity (CS\u00a0=\u00a00, <jats:italic>n<\/jats:italic>\u00a0=\u00a06). In two cases each, ceHT2\u2010FLAIR either enabled diagnosis or provided supporting information. In six cases, it confirmed diagnosis based on noncontrast imaging. Beyond improved conspicuity, ceHT2\u2010FLAIR helped detect low\u2010flow leaks, optimize axial slice positioning, and assess CSF lamella distribution.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Intravenous ceHT2\u2010FLAIR MRI may be considered as an additional tool in CSF leak evaluation, particularly when used for detecting indirect signs of IH.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jon.70056","type":"journal-article","created":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T05:56:44Z","timestamp":1748411804000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Intravenous Contrast\u2010Enhanced MR Myelography in CSF Leakage for the Detection of Spinal CSF Lamellae"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6029-7297","authenticated-orcid":false,"given":"Zeynep","family":"Bendella","sequence":"first","affiliation":[{"name":"Department of Neuroradiology, University Medical Center Bonn Rheinische Friedrich\u2010Wilhelms\u2010Universit\u00e4t Bonn  Bonn Germany"},{"name":"Clinical Neuroimaging Group German Center for Neurodegenerative Diseases (DZNE)  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Haase","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, University Medical Center Bonn Rheinische Friedrich\u2010Wilhelms\u2010Universit\u00e4t Bonn  Bonn Germany"},{"name":"Clinical Neuroimaging Group German Center for Neurodegenerative Diseases (DZNE)  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf","family":"Clauberg","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, University Medical Center Bonn Rheinische Friedrich\u2010Wilhelms\u2010Universit\u00e4t Bonn  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Z\u00fclow","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, University Medical Center Bonn Rheinische Friedrich\u2010Wilhelms\u2010Universit\u00e4t Bonn  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Kindler","sequence":"additional","affiliation":[{"name":"Section of Vascular Neurology, Department for Neurology Universit\u00e4tsklinikum Bonn  Bonn Germany"},{"name":"Department of Old Age Psychiatry and Cognitive Disorders, University Hospital Bonn University of Bonn  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Radbruch","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, University Medical Center Bonn Rheinische Friedrich\u2010Wilhelms\u2010Universit\u00e4t Bonn  Bonn Germany"},{"name":"Clinical Neuroimaging Group German Center for Neurodegenerative Diseases (DZNE)  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Paech","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, University Medical Center Bonn Rheinische Friedrich\u2010Wilhelms\u2010Universit\u00e4t Bonn  Bonn Germany"},{"name":"Department of Radiology Brigham and Women's Hospital, Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katerina","family":"Deike","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, University Medical Center Bonn Rheinische Friedrich\u2010Wilhelms\u2010Universit\u00e4t Bonn  Bonn Germany"},{"name":"Athinoula A. Martinos Center for Biomedical Imaging Massachusetts General Hospital  Charlestown Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.15.14884"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nic.2019.07.006"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2020.4799"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000163093.38616.35"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318212ab43"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.57.10.1921"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2008.01777.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.295.19.2286"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A3975"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.11.8238"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A1277"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2982.2007.01376.x"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcma.2016.02.013"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A0746"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.12421"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181fc2997"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awv016"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/RLI.0000000000000533"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2011.01911.x"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102417738202"},{"key":"e_1_2_8_22_1","article-title":"Intravenous Enhanced 3D FLAIR Imaging to Identify CSF Leaks in Spontaneous Intracranial Hypotension: Comparison With MR Myelography","volume":"13","author":"Osawa I.","year":"2012","journal-title":"European Journal of Radiology Open"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.2463\/mrms.9.237"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A0920"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181c3fd99"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1080\/02841850701769785"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A7841"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00062-021-01060-y"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A1937"}],"container-title":["Journal of Neuroimaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jon.70056","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T11:23:25Z","timestamp":1750937005000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jon.70056"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":28,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["10.1111\/jon.70056"],"URL":"https:\/\/doi.org\/10.1111\/jon.70056","archive":["Portico"],"relation":{},"ISSN":["1051-2284","1552-6569"],"issn-type":[{"value":"1051-2284","type":"print"},{"value":"1552-6569","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"2025-04-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70056"}}