{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T07:18:39Z","timestamp":1783667919173,"version":"3.55.0"},"reference-count":19,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,8,3]],"date-time":"2025-08-03T00:00:00Z","timestamp":1754179200000},"content-version":"vor","delay-in-days":33,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neuroimaging"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and purpose<\/jats:title>\n                    <jats:p>Optic nerve sheath diameter (ONSD) measured by point\u2010of\u2010care ultrasound (POCUS) is a commonly used non\u2010invasive estimate of intracranial pressure (ICP). However, methodological variations limit standardization of this promising technique. Different imaging axes are identified as one such source of ONSD POCUS methodological variation. This study aimed to evaluate the agreement and diagnostic accuracy for elevated ICP between transverse and sagittal ONSD measurements.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a post\u2010hoc analysis of 213 intensive care patients from three prior studies. ONSD was measured in both transverse and sagittal planes, externally (ONSDext) and internally (ONSDint) of the dura mater. Agreement was assessed using Lin's concordance correlation coefficient (CCC). Diagnostic accuracy for detecting ICP \u226520\u00a0mmHg was evaluated using area under the receiver operator characteristics curve (AUROC) analyses in a subset of 139 patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Sagittal ONSD was significantly larger than transverse ONSD (median difference 0.2\u00a0mm, p&lt;0.001). Agreement between transverse and sagittal ONSD was poor (CCC: 0.65 and 0.70 for right and left side ONSDext, and 0.43 and 0.51 for right and left side ONSDint). No significant differences in AUROC were found between transverse, sagittal, or averaged measurements.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Transverse and sagittal ONSD measurements are not interchangeable due to significant differences and poor agreement. Diagnostic accuracy was similar across methods. These findings support continued use of transverse measurement as the standard approach for ONSD POCUS in clinical practice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jon.70076","type":"journal-article","created":{"date-parts":[[2025,8,4]],"date-time":"2025-08-04T05:49:56Z","timestamp":1754286596000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Optic Nerve Sheath Diameter: Which Axis Should Be Measured?"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6665-0589","authenticated-orcid":false,"given":"Jakob","family":"Pansell","sequence":"first","affiliation":[{"name":"The Department of Clinical Neuroscience Karolinska Institutet  Stockholm Sweden"},{"name":"The Department of Anesthesia and Intensive Care Medicine Karolinska University Hospital  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tina","family":"Thomsson","sequence":"additional","affiliation":[{"name":"The Department of Clinical Neuroscience Karolinska Institutet  Stockholm Sweden"},{"name":"The Department of Anesthesia and Intensive Care Medicine Karolinska University Hospital  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emelie","family":"Eng","sequence":"additional","affiliation":[{"name":"The Department of Clinical Neuroscience Karolinska Institutet  Stockholm Sweden"},{"name":"The Department of Anesthesia and Intensive Care Medicine Karolinska University Hospital  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Wallin","sequence":"additional","affiliation":[{"name":"The Department of Neurobiology Care Sciences and Society Division of Physiotherapy Karolinska Institutet  Huddinge Sweden"},{"name":"Women's Health and Allied Health Professionals Theme Medical Unit Allied Health Professionals Karolinska University Hospital  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Hirzallah","sequence":"additional","affiliation":[{"name":"Departments of Neurology and Neurosurgery Baylor College of Medicine  Houston Texas USA"},{"name":"Center for Space Medicine Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,3]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)73195-2"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jon.13018"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jon.12906"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNO.0000000000001942"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10877-023-01067-5"},{"key":"e_1_2_7_7_1","first-page":"16","article-title":"Ultrasound Measurement of Optic Nerve Sheath Diameter in a Healthy Adult Colombian Population","volume":"23","author":"Trocha G.","year":"2023","journal-title":"BMC Neurology [Electronic 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