{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T11:08:09Z","timestamp":1789038489148,"version":"build-2803163510"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T00:00:00Z","timestamp":1756857600000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neuroimaging"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Alzheimer's disease (AD) and mild cognitive impairment (MCI) are two common conditions associated with cognitive decline. With global dementia cases rising, identifying the most accurate imaging method for diagnosis is essential.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Following Preferred Reporting Items for Systematic review and Meta\u2010Analysis Protocols, we systematically reviewed studies utilizing arterial spin labeling magnetic resonance imaging (ASL\u2010MRI) and [18F]\u20102\u2010fluoro\u20102\u2010deoxy\u2010D\u2010glucose positron emission tomography (FDG\u2010PET) for neurodegenerative disorders. Searches in PubMed\/MEDLINE, Scopus, and Embase led to 17 studies directly comparing these modalities for MCI\/AD diagnosis. Seven studies met criteria for meta\u2010analysis based on interreader agreement and area under the curve (AUC) data. Meta\u2010analysis was performed using the R \u201cMada\u201d package, with study heterogeneity assessed via the Zhou and Dendukuri approach.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Meta\u2010analysis of seven studies showed FDG\u2010PET had a slightly higher AUC (0.864, sensitivity 0.81, specificity 0.80) compared to ASL\u2010MRI (AUC 0.836, sensitivity 0.73, specificity 0.80), but no statistically significant difference. Low heterogeneity was observed (\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      : 9.4% for FDG\u2010PET, 6.5% for ASL\u2010MRI). In MCI subgroup analysis, FDG\u2010PET outperformed ASL\u2010MRI with significantly higher sensitivity (0.90\u00a0vs. 0.75), specificity (0.91\u00a0vs. 0.73), and AUC (0.92\u00a0vs. 0.80,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>FDG\u2010PET and ASL\u2010MRI demonstrate comparable diagnostic accuracy for AD and MCI. Selection between modalities may depend on availability, cost, and safety considerations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Relevance\/Application<\/jats:title>\n                    <jats:p>Both FDG\u2010PET and MRI\u2010ASL are effective at identifying MCI and AD, enabling accurate diagnosis. The choice of which modality to use may be addressed by cost, availability, and consideration of other potential diagnoses.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jon.70080","type":"journal-article","created":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T07:04:24Z","timestamp":1756883064000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Functional Imaging in Alzheimer's Disease: A Systematic Review and Meta\u2010Analysis of ASL\u2010MRI and FDG\u2010PET"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6039-3772","authenticated-orcid":false,"given":"Mahla","family":"Radmard","sequence":"first","affiliation":[{"name":"Russell H. Morgan Department of Radiology and Radiological Science Johns Hopkins Medical Institution  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mona","family":"Gad","sequence":"additional","affiliation":[{"name":"Diagnostic Radiology Department Mansoura University  Mansoura Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Sheikhy","sequence":"additional","affiliation":[{"name":"Radiology and Imaging Sciences Clinical Center National Institutes of Health  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Dagher","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology MD Anderson Cancer Center  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2450-4014","authenticated-orcid":false,"given":"Vivek","family":"Yedavalli","sequence":"additional","affiliation":[{"name":"Russell H. Morgan Department of Radiology and Radiological Science Johns Hopkins Medical Institution  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Licia P.","family":"Luna","sequence":"additional","affiliation":[{"name":"Russell H. Morgan Department of Radiology and Radiological Science Johns Hopkins Medical Institution  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1099-1166(199907)14:7<526::AID-GPS965>3.0.CO;2-0"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1590\/1516-4446-2012-3503"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-020-04694-1"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2012.11.007"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-017-4784-1"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.13.12363"},{"issue":"1","key":"e_1_2_8_8_1","first-page":"49","article-title":"Progression to Dementia in a Population With Amnestic Mild Cognitive Impairment: Clinical Variables Associated With 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