{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T08:07:55Z","timestamp":1783930075305,"version":"3.55.0"},"reference-count":45,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,9,7]],"date-time":"2025-09-07T00:00:00Z","timestamp":1757203200000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neuroimaging"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Purpose<\/jats:title>\n                    <jats:p>To review the existing evidence on multiple timepoint assessments of optic nerve sheath diameter (ONSD) as an indicator of intraindividual variation of intracranial pressure (ICP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic search identified studies assessing intraindividual variation in ICP through multiple timepoint measurements of ONSD using ultrasonography. Meta\u2010analysis of studies assessing intraindividual correlation coefficients between ONSD and ICP was performed using a random effects model, and we calculated the weighted correlation coefficient for the expected change in ICP associated with variations in ONSD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of five studies, comprising 157 patients, were included in the review. ONSD was compared with invasive ICP measurement methods at multiple timepoints. Meta\u2010analysis of intraindividual ONSD\u2013ICP correlation demonstrated a correlation coefficient of 0.62 (CI: 0.50\u20130.71). Individual linear correlation analyses were performed in two of the studies, yielding correlation coefficients ranging from 0.79 to 1.00; however, widely variable individual slopes were found (1.51\u201341.43\u00a0mm\/mmHg). ONSD variations ranged from 0.12 to 3.30\u00a0mm per 5\u00a0mmHg change in ICP, with a variation of 0.55\u00a0mm in adults with hypoxic brain injury and 0.77\u00a0mm in children with idiopathic intracranial hypertension.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our findings indicate that ONSD significantly correlates with ICP, and longitudinal intraindividual assessment shows a predominantly linear correlation between both variables. A personalized ONSD\u2013ICP correlation equation may enable accurate ICP prediction, making ONSD a useful tool for follow\u2010up in patients with previous invasive ICP measurements, when adjusted to each patient's characteristics and pathologies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jon.70083","type":"journal-article","created":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T03:32:13Z","timestamp":1757302333000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Intraindividual Optic Nerve Sheath Variation and Intracranial Pressure Changes: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-7840-6231","authenticated-orcid":false,"given":"Henrique","family":"Azevedo","sequence":"first","affiliation":[{"name":"Faculdade de Medicina Universidade de Lisboa Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lia Lucas","family":"Neto","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina Universidade de Lisboa Lisbon Portugal"},{"name":"Neurologic Imaging Department ULS Santa Maria  Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1851-7182","authenticated-orcid":false,"given":"David","family":"Berhanu","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina Universidade de Lisboa Lisbon Portugal"},{"name":"Neuroradiology Department ULS S\u00e3o Jos\u00e9, Lisbon Clinical Academic Centre  Lisbon Portugal"},{"name":"CRI\u2010EM ULS S\u00e3o Jos\u00e9, Lisbon Clinical Academic Centre  Lisbon Portugal"},{"name":"Cat\u00f3lica Medical School  Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,7]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-022-06786-y"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/CON.0000000000000665"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12987-019-0129-6"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccc.2022.08.002"},{"issue":"1","key":"e_1_2_7_6_1","first-page":"S37","article-title":"Diagnosis and Management of Increased Intracranial Pressure","volume":"49","author":"Dennis L. 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