{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T07:39:48Z","timestamp":1792049988691,"version":"4.4.0"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T00:00:00Z","timestamp":1756857600000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neuroimaging"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Purpose<\/jats:title>\n                    <jats:p>Diffusion tensor imaging analysis along the perivascular space (DTI\u2010ALPS) has emerged as a promising noninvasive method for evaluating water motion that may reflect glymphatic system function. However, the reliability of DTI\u2010ALPS measurements across different region\u2010of\u2010interest (ROI) selection methods remains underinvestigated. This study aimed to assess the interrater reliability among three neuroradiologists in native space and compare DTI\u2010ALPS indices derived from ROIs placed in subjects\u2019 native space versus standardized Montreal Neurological Institute (MNI) space.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>DTI\u2010ALPS indices from 16 healthy subjects were calculated from both left and right hemispheres using two ROI placement approaches: (1) native space ROIs manually placed by three neuroradiologists, and (2) standardized ROIs in MNI space based on the fractional anisotropy template. Interrater reliability was assessed using intraclass correlation coefficients (ICCs). The proportion of ROI overlaps among the three neuroradiologists was also evaluated. Differences between native and MNI space measurements were evaluated using related\u2010samples Friedman's analysis with post hoc pairwise comparisons.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Interrater reliability for native space ROI placement was moderate for left\u2010sided DTI\u2010ALPS indices (ICC\u00a0=\u00a00.599) and good for right\u2010sided DTI\u2010ALPS indices (ICC\u00a0=\u00a00.807). Spatial overlap analysis revealed poor Dice similarity coefficients across all ROI types (range: 0.047\u20130.312), with right association ROIs showing higher spatial consistency. Significant differences were found between native and MNI space measurements for left\u2010sided DTI\u2010ALPS indices (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.002) but not for right\u2010sided DTI\u2010ALPS indices (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.913).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings highlight the importance of standardized ROI selection approaches for clinical applications of DTI\u2010ALPS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jon.70086","type":"journal-article","created":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T05:40:27Z","timestamp":1756964427000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Reliability and Spatial Consistency of MR Diffusion Tensor Imaging Measures Along the Cerebral Perivascular Space"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-9393-3857","authenticated-orcid":false,"given":"Enchao","family":"Qiu","sequence":"first","affiliation":[{"name":"Jefferson Headache Center, Department of Neurology Thomas Jefferson University  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joga","family":"Chaganti","sequence":"additional","affiliation":[{"name":"Jefferson Integrative Magnetic Resonance Imaging Center, Department of Radiology Thomas Jefferson University  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillip","family":"Phan","sequence":"additional","affiliation":[{"name":"Jefferson Headache Center, Department of Neurology Thomas Jefferson University  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahdi","family":"Alizadeh","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Thomas Jefferson University  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devon","family":"Middleton","sequence":"additional","affiliation":[{"name":"Jefferson Integrative Magnetic Resonance Imaging Center, Department of Radiology Thomas Jefferson University  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiran","family":"Talekar","sequence":"additional","affiliation":[{"name":"Jefferson Integrative Magnetic Resonance Imaging Center, Department of Radiology Thomas Jefferson University  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prabath K.","family":"Mondel","sequence":"additional","affiliation":[{"name":"Jefferson Integrative Magnetic Resonance Imaging Center, Department of Radiology Thomas Jefferson University  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott H.","family":"Faro","sequence":"additional","affiliation":[{"name":"Jefferson Integrative Magnetic Resonance Imaging Center, Department of Radiology Thomas Jefferson University  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feroze B.","family":"Mohamed","sequence":"additional","affiliation":[{"name":"Jefferson Integrative Magnetic Resonance Imaging Center, Department of Radiology Thomas Jefferson University  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4536-9974","authenticated-orcid":false,"given":"Hsiangkuo","family":"Yuan","sequence":"additional","affiliation":[{"name":"Jefferson Headache Center, Department of Neurology Thomas Jefferson University  Philadelphia Pennsylvania 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