{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T06:58:44Z","timestamp":1778223524960,"version":"3.51.4"},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T00:00:00Z","timestamp":1762128000000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neuroimaging"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Purpose<\/jats:title>\n                    <jats:p>Several studies have demonstrated the amelioration of refractory migraines with middle meningeal artery (MMA) intra\u2010arterial lidocaine infusion, but the durability beyond 1 month is not well studied, and the angiographic dose response of lidocaine infusion was not previously evaluated. We aimed to assess the efficacy of middle meningeal artery lidocaine infusion in the treatment of refractory migraines at a 3\u2010month follow\u2010up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We quantified the response to intra\u2010arterial lidocaine infusion (maximum dose of 150\u00a0mg) in patients with refractory migraine using the Migraine Disability Assessment (MIDAS) evaluated pre\u2010 and posttreatment. At 3 months, We determined the MIDAS score changes, the proportion of responders (\u226550% MIDAS reduction), the proportion of patients with \u201cno disability\u201d (MIDAS Grade 1), and the cessation of opioid medication for headache management measured at the last known follow\u2010up. An angiographic dose response was quantified.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Eight patients were included in our analysis (mean age of 49.1\u00a0\u00b1\u00a013.2 years; 87.5% were women). The cohort comprised equal numbers of unilateral and bilateral MMA lidocaine infusions (4 each), with doses titrated from 50 to 150\u00a0mg per procedure. At 3 months posttreatment, the mean MIDAS score improved from 86.3\u00a0\u00b1\u00a040.1 to 23.5\u00a0\u00b1\u00a026.8 (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.001, paired\n                      <jats:italic>t<\/jats:italic>\n                      \u2010test), and 62.5% of the patients showed 50% MIDAS score reduction. The disability pre\u2010treatment was classified as \u201csevere disability\u201d in all patients, and 50% achieved \u201cno disability\u201d (MIDAS Grade 1) at 3 months posttreatment. No adverse events were reported in any of the procedures. At last known follow\u2010up of a median period of 9.8 months [range 4\u201321 months], three out of the four patients who were on opioid medication pre\u2010treatment discontinued their opioid medications following MMA lidocaine infusion.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Intra\u2010arterial lidocaine infusion was associated with sustained improvement at 3 months posttreatment in 50% of patients with refractory migraines.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jon.70096","type":"journal-article","created":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T06:56:07Z","timestamp":1762239367000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Middle Meningeal Artery Lidocaine Infusion for Refractory Migraine: Angiographic Dose Response and 3\u2010Month Outcomes"],"prefix":"10.1111","volume":"35","author":[{"given":"Rami","family":"Fakih","sequence":"first","affiliation":[{"name":"Centra Medical Group Neurosurgery  Lynchburg Virginia USA"},{"name":"Department of Neurology University of Missouri  Columbia Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4461-187X","authenticated-orcid":false,"given":"Nived Jayaraj","family":"Ranjini","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Missouri  Columbia Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Syed A.","family":"Gillani","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Missouri  Columbia Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimberley","family":"Pfeiffer","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Missouri  Columbia Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camilo R.","family":"Gomez","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Missouri  Columbia Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Sirakov","sequence":"additional","affiliation":[{"name":"Department of Radiology UH St. Ivan Rilski  Sofia Bulgaria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Fareed K.","family":"Suri","sequence":"additional","affiliation":[{"name":"Department of Neurology Aspirus St. Luke's Stroke Center  Duluth Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Bhogal","sequence":"additional","affiliation":[{"name":"Department of Interventional Neuroradiology The Royal London Hospital  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4962-540X","authenticated-orcid":false,"given":"Adnan I.","family":"Qureshi","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Missouri  Columbia Missouri USA"},{"name":"Zeenat Qureshi Stroke Institute  St. Cloud Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,3]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnis\u20102023\u2010021148"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10194\u2010019\u20101040\u2010x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10194\u2010019\u20101068\u2010y"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.21857"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.4103\/0972\u20102327.99993"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jon.12918"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnis\u20102025\u2010023246"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/0333102417738202"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4610.2001.01156.x"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468\u20102982.1999.019002107.x"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10194\u2010021\u201001339\u2010y"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/15910199241307049"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542\u2010200209000\u201000031"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/rapm\u20102021\u2010103180"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/15910199231195470"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.14071"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-198304000-00001"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.2147\/LRA.S154512"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(13)70067\u2010X"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.13298"}],"container-title":["Journal of Neuroimaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jon.70096","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T02:53:45Z","timestamp":1767063225000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jon.70096"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":20,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1111\/jon.70096"],"URL":"https:\/\/doi.org\/10.1111\/jon.70096","archive":["Portico"],"relation":{},"ISSN":["1051-2284","1552-6569"],"issn-type":[{"value":"1051-2284","type":"print"},{"value":"1552-6569","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"2025-07-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70096"}}