{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T03:39:34Z","timestamp":1767065974458,"version":"3.48.0"},"reference-count":43,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T00:00:00Z","timestamp":1762819200000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004243","name":"Prinses Beatrix Spierfonds","doi-asserted-by":"publisher","award":["W.OB18\u201003"],"award-info":[{"award-number":["W.OB18\u201003"]}],"id":[{"id":"10.13039\/501100004243","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neuroimaging"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Purpose<\/jats:title>\n                    <jats:p>\n                      Small fiber neuropathy (SFN) is a neuropathic disorder that is associated with chronic pain. While most SFN cases are idiopathic, SFN can also have hereditary causes. For example, rare SCN9A gene mutations can impair the Na\n                      <jats:sub>V<\/jats:sub>\n                      1.7 sodium channel, which leads to dorsal root ganglion neuron hyperexcitability, causing SFN. Although chronic pain may induce cerebral changes, the specific structural brain alterations in SCN9A\u2010associated SFN (SFN\u2010SCN9A) remain insufficiently characterized. Therefore, potential alterations in the structural brain network of idiopathic SFN and SFN\u2010SCN9A were explored.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Ten SFN\u2010SCN9A patients, 20 idiopathic SFN patients, and 20 controls were included. All participants underwent 3\u2010Tesla diffusion MRI (66 gradient directions,\n                      <jats:italic>b<\/jats:italic>\n                      \u2010value\u00a0=\u00a01200 s\/mm\n                      <jats:sup>2<\/jats:sup>\n                      ), and the brain network was quantified using nodal importance, which describes the influence of a group of regions on the whole network.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The nodal importance of pain\u2010associated regions (postcentral gyrus, insular cortex, anterior cingulate cortex, and thalamus) was increased in SFN\u2010SCN9A patients compared to controls (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u00a0=\u00a00.43,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.02) and idiopathic SFN patients (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u00a0=\u00a00.43,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.02). Moreover, higher self\u2010reported pain was associated with higher nodal importance of pain\u2010associated regions in the SFN\u2010SCN9A group (\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u00a00.67,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.03), while this effect was not observed in the idiopathic SFN patients (\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u00a0\u22120.22,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.34). As self\u2010reported pain did not differ between the SFN groups, it is likely specific to the SCN9A\u2010mutation and not to differences in pain intensity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Combined, these results suggest the potential involvement of a distinct structural pathway related to pain processing in SFN\u2010SCN9A.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jon.70105","type":"journal-article","created":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T11:34:11Z","timestamp":1762860851000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Diffusion Tensor Imaging Reveals Altered Centrality of Pain\u2010Related Regions in SCN9A\u2010Associated Small Fiber Neuropathy"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7708-8501","authenticated-orcid":false,"given":"Gerhard S.","family":"Drenthen","sequence":"first","affiliation":[{"name":"Department of Radiology and Nuclear Medicine Maastricht University Medical Center  Maastricht The Netherlands"},{"name":"Mental Health and Neuroscience Research Institute (MHeNs) Maastricht University Medical Center  Maastricht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5385-7575","authenticated-orcid":false,"given":"Dennis","family":"Kool","sequence":"additional","affiliation":[{"name":"Mental Health and Neuroscience Research Institute (MHeNs) Maastricht University Medical Center  Maastricht The Netherlands"},{"name":"Department of Neurology Maastricht University Medical Center  Maastricht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amir","family":"Far","sequence":"additional","affiliation":[{"name":"Mental Health and Neuroscience Research Institute (MHeNs) Maastricht University Medical Center  Maastricht The Netherlands"},{"name":"Department of Neurology Maastricht University Medical Center  Maastricht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8682-163X","authenticated-orcid":false,"given":"Jaymin","family":"Upadhyay","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Critical Care and Pain Medicine Boston Children's Hospital, Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5638-9292","authenticated-orcid":false,"given":"David E. J.","family":"Linden","sequence":"additional","affiliation":[{"name":"Mental Health and Neuroscience Research Institute (MHeNs) Maastricht University Medical Center  Maastricht The Netherlands"},{"name":"Department of Neurology Maastricht University Medical Center  Maastricht The Netherlands"},{"name":"Department of Psychiatry and Neuropsychology, Faculty of Health, Medicine and Life Sciences Maastricht University  Maastricht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6486-2388","authenticated-orcid":false,"given":"Raquel","family":"van Gool","sequence":"additional","affiliation":[{"name":"Mental Health and Neuroscience Research Institute (MHeNs) Maastricht University Medical Center  Maastricht The Netherlands"},{"name":"Department of Anesthesiology, Critical Care and Pain Medicine Boston Children's Hospital, Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Celine P.","family":"Goijen","sequence":"additional","affiliation":[{"name":"Department of Neurology Maastricht University Medical Center  Maastricht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingemar S. J.","family":"Merkies","sequence":"additional","affiliation":[{"name":"Mental Health and Neuroscience Research Institute (MHeNs) Maastricht University Medical Center  Maastricht The Netherlands"},{"name":"Department of Neurology Curacao Medical Center  Willemstad Curacao"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7905-0681","authenticated-orcid":false,"given":"Walter H.","family":"Backes","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine Maastricht University Medical Center  Maastricht The Netherlands"},{"name":"Mental Health and Neuroscience Research Institute (MHeNs) Maastricht University Medical Center  Maastricht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2467-067X","authenticated-orcid":false,"given":"Catharina G.","family":"Faber","sequence":"additional","affiliation":[{"name":"Mental Health and Neuroscience Research Institute (MHeNs) Maastricht University Medical Center  Maastricht The Netherlands"},{"name":"Department of Neurology Maastricht University Medical Center  Maastricht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5271-8060","authenticated-orcid":false,"given":"Jacobus F. 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