{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T01:56:02Z","timestamp":1781920562104,"version":"3.54.5"},"reference-count":34,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,11,15]],"date-time":"2025-11-15T00:00:00Z","timestamp":1763164800000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01NS134712"],"award-info":[{"award-number":["R01NS134712"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01NS114382"],"award-info":[{"award-number":["R01NS114382"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000052","name":"NIH Office of the Director","doi-asserted-by":"publisher","award":["S10OD032285"],"award-info":[{"award-number":["S10OD032285"]}],"id":[{"id":"10.13039\/100000052","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neuroimaging"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Purpose<\/jats:title>\n                    <jats:p>Cranioplasty reconstruction after hemicraniectomy restores skull integrity and has been associated with neurological improvement, but the physiological mechanisms underlying recovery remain incompletely understood. This study investigated cerebral blood flow (CBF), arterial transit time (ATT), and blood\u2013brain barrier (BBB) water exchange rate (Kw) as imaging metrics of hemodynamic recovery following cranioplasty.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Fourteen patients (mean age: 33.4 \u00b1 8.53 years; 2 females, 12 males) who previously underwent hemicraniectomy for traumatic brain injury, ruptured aneurysm, or hemorrhagic stroke were included. All participants underwent diffusion\u2010prepared pseudo\u2010continuous arterial spin labeling (DP\u2010pCASL) Magnetic Resonance Imaging (MRI) at 3 Tesla before and after cranioplasty. Hemodynamic parameters were quantified globally and regionally, with particular focus on the middle cerebral artery perforator (MCA Perf) territory.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Post\u2010surgical imaging revealed significant increases in CBF within the ipsilateral MCA Perf territory compared to pre\u2010surgical values. BBB Kw asymmetry between MCA Perf territories also improved, indicating enhanced perfusion and BBB function in the impacted hemisphere. ATT changes were region\u2010specific, with significant increases in asymmetry observed in the leptomeningeal anterior cerebral artery and posterior cerebral artery territories, but not in the MCA Perf region.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings underscore the mechanobiological role of cranioplasty reconstruction in neurological recovery. Advanced hemodynamic imaging with DP\u2010pCASL MRI provides quantitative insight into cerebral perfusion, BBB function, and regional perfusion timing. This approach may guide future research on post\u2010cranioplasty recovery and inform personalized rehabilitation strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jon.70106","type":"journal-article","created":{"date-parts":[[2025,11,15]],"date-time":"2025-11-15T08:15:56Z","timestamp":1763194556000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Cerebral Perfusion and Blood\u2212Brain Barrier Changes After Cranioplasty: A Diffusion\u2010Prepared Arterial Spin Labeling Study"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8163-5240","authenticated-orcid":false,"given":"Brandon","family":"Ojogho","sequence":"first","affiliation":[{"name":"Laboratory of Functional MRI Technology (LOFT) Stevens Neuroimaging &amp; Informatics Institute Keck School of Medicine of USC  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aidin","family":"Abedi","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darrin J.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingfeng","family":"Shao","sequence":"additional","affiliation":[{"name":"Laboratory of Functional MRI Technology (LOFT) Stevens Neuroimaging &amp; Informatics Institute Keck School of Medicine of USC  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Russin","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kay","family":"Jann","sequence":"additional","affiliation":[{"name":"Laboratory of Functional MRI Technology (LOFT) Stevens Neuroimaging &amp; Informatics Institute Keck School of Medicine of USC  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles Y.","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, USC Neurorestoration Center and Rancho Los Amigos National Rehabilitation Center University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danny J. J.","family":"Wang","sequence":"additional","affiliation":[{"name":"Laboratory of Functional MRI Technology (LOFT) Stevens Neuroimaging &amp; Informatics Institute Keck School of Medicine of USC  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,15]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3171\/2016.10.JNS16678"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurol.2012.06.016"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuros\/nyx054"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12893\u2010025\u201002943\u20104"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.25259\/SNI_1003_2023"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.61.2.166"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2022.823857"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010023\u201035768\u20103"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.3171\/2014.6.JNS132838"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.3171\/2017.4.JNS163036"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2010.1443"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3171\/2019.7.JNS191077"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fsurg.2022.864385"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.29581"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.27632"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330\u2010023\u201009652\u20107"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1101\/2024.01.12.575463"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12357"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.70089"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.50.6.1699"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuros\/nyx182"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10143-021-01668-1"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11910\u2010021\u201001147\u20106"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0000000000008724"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2003.06.005"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/ca.1032"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cortex.2013.10.009"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1159\/000333606"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl158"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/jon.13058"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2005.03.012"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2020.571480"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp\u20102021\u2010328519"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12987\u2010023\u201000464\u2010x"}],"container-title":["Journal of Neuroimaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jon.70106","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T02:53:41Z","timestamp":1767063221000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jon.70106"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":34,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1111\/jon.70106"],"URL":"https:\/\/doi.org\/10.1111\/jon.70106","archive":["Portico"],"relation":{},"ISSN":["1051-2284","1552-6569"],"issn-type":[{"value":"1051-2284","type":"print"},{"value":"1552-6569","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"2025-08-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70106"}}