{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T03:39:09Z","timestamp":1767065949919,"version":"3.48.0"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T00:00:00Z","timestamp":1764288000000},"content-version":"vor","delay-in-days":27,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neuroimaging"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Purpose<\/jats:title>\n                    <jats:p>Idiopathic normal pressure hydrocephalus (iNPH) is a neurological disorder that primarily affects older adults and is typically characterized clinically by a triad of symptoms: gait disturbance, urinary urgency or incontinence, and cognitive decline. The relationship between clinical presentation and iNPH imaging biomarkers remains unclear, as does the ability of these markers to predict outcomes following cerebrospinal fluid diversion. Additionally, the association between fecal incontinence (FI) and iNPH, as well as the relationship between FI and iNPH imaging biomarkers, is poorly understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective review was conducted on 125 consecutive iNPH patients treated by a single surgeon at Brigham and Women's Hospital between 2015 and 2023. Patients were treated with the placement of a ventriculoperitoneal (VP) shunt. Patient demographics, symptoms, and clinical improvement were recorded at 3 and 12\u00a0months post\u2010shunt placement. Imaging biomarkers, including Evans Index (EI), callosal angle (CA), anteroposterior diameter of the lateral ventricle index (ALVI), and disproportionately enlarged subarachnoid space hydrocephalus score, were measured using preoperative imaging.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 125 patients (mean age 74.8\u00a0years, 71 males), 124 presented with gait disturbance, 113 with urinary dysfunction, and 111 with cognitive decline. FI was present in 24 patients. Patients with preoperative FI had higher EI and ALVI. Patients with improved FI at 3\u2010month follow\u2010up had larger CA. Patients with improved gait at 12\u2010month follow\u2010up had smaller EI and ALVI scores. Patients with preoperative urinary symptoms had a higher EI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Imaging biomarkers can have both diagnostic utility and predictive potential for outcomes related to specific symptoms following CSF diversion with VP shunts.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jon.70109","type":"journal-article","created":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T06:00:14Z","timestamp":1764396014000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Imaging Biomarkers in Idiopathic Normal Pressure Hydrocephalus: Associations With Symptoms and 1\u2010Year Treatment Outcomes"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-4529-3521","authenticated-orcid":false,"given":"Colin P.","family":"Galvin","sequence":"first","affiliation":[{"name":"Department of Neurosurgery Brigham and Women's Hospital, Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ben","family":"Phan","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Brigham and Women's Hospital, Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leo","family":"Zekelman","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Brigham and Women's Hospital, Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Vangel","sequence":"additional","affiliation":[{"name":"Department of Medicine Massachusetts General Hospital, Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary Beth","family":"Anketell","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Brigham and Women's Hospital, Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erickson","family":"Torio","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Brigham and Women's Hospital, Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra J.","family":"Golby","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Brigham and Women's Hospital, Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frederic","family":"Racicot","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Brigham and Women's Hospital, Harvard Medical School  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,28]]},"reference":[{"volume-title":"StatPearls","year":"2024","author":"Das J. 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(n.d.). [Computer software]. \u201cVisage Imaging.\u201d Retrieved December 1 2024 fromhttps:\/\/visageimaging.com\/."},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A4046"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.3171\/2016.9.JNS161080"},{"key":"e_1_2_7_16_1","first-page":"380","article-title":"Effect of Abdominal Insufflation for Laparoscopy on Intracranial Pressure","volume":"149","author":"Kamine T. 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