{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T14:55:14Z","timestamp":1785164114512,"version":"3.55.0"},"reference-count":90,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T00:00:00Z","timestamp":1764460800000},"content-version":"vor","delay-in-days":29,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neuroimaging"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Neurodegeneration with brain iron accumulation (NBIA) refers to a group of rare genetic disorders characterized by abnormal iron deposition in the basal ganglia and brainstem due to impaired iron homeostasis. Disease severity and manifestations vary according to the underlying genetic mutation and age of presentation; however, most subtypes share progressive neurological features such as dystonia, Parkinsonism, spasticity, cognitive decline, and intellectual disability.<\/jats:p>\n                  <jats:p>In this review, we first outline the physiological role of iron in the central nervous system, emphasizing its importance for neurotransmitter synthesis, myelination, and mitochondrial metabolism, and discuss how disruption of homeostatic mechanisms may lead to ferroptosis and neuronal injury. We then explore the role of neuroimaging in the diagnosis of NBIA, with a focus on MRI as the modality of choice. Finally, we provide an overview of the clinical and imaging features of the major NBIA subtypes, highlighting both shared characteristics and distinctive patterns. Covered NBIA include primary disorders of iron metabolism, such as neuroferritinopathy and aceruloplasminemia, and secondary disorders with disrupted iron regulation, including Pantothenate Kinase\u2010Associated Neurodegeneration, Phospholipase A2 Group VI\u2010Associated Neurodegeneration, Mitochondrial Membrane Protein\u2010Associated Neurodegeneration, Beta\u2010Propeller Protein\u2010Associated Neurodegeneration, Fatty Acid Hydroxylase\u2010Associated Neurodegeneration, Coenzyme A Synthetase Protein\u2010Associated Neurodegeneration, Woodhouse\u2013Sakati syndrome, and Kufor\u2013Rakeb Disease. By integrating genetics, pathophysiology, and imaging, this review aims to improve recognition of NBIA and support comprehensive clinical management.<\/jats:p>","DOI":"10.1111\/jon.70112","type":"journal-article","created":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T04:20:11Z","timestamp":1764562811000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Neurodegeneration With Brain Iron Accumulation and Ferroptosis Disorders in Children and Adults: An Imaging Review"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0199-808X","authenticated-orcid":false,"given":"Livja","family":"Mertiri","sequence":"first","affiliation":[{"name":"Edward B. 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Singleton Department of Radiology Texas Children's Hospital and Baylor College of Medicine  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Rossi","sequence":"additional","affiliation":[{"name":"Neuroradiology Unit IRCCS Istituto Giannina Gaslini  Genoa Italy"},{"name":"Department of Health Sciences (DISSAL) University of Genoa  Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Hoffmann","sequence":"additional","affiliation":[{"name":"Department of Radiology Sheba Medical Center  Ramat\u2010Gan Israel"},{"name":"Faculty of Medicine Tel\u2010Aviv University  Tel\u2010Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry A. G. M.","family":"Huisman","sequence":"additional","affiliation":[{"name":"Edward B. 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