{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T19:57:04Z","timestamp":1772999824223,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T00:00:00Z","timestamp":1770163200000},"content-version":"vor","delay-in-days":34,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["852173"],"award-info":[{"award-number":["852173"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002996","name":"Hartstichting","doi-asserted-by":"publisher","award":["03\u2013001\u20132022\u20130157"],"award-info":[{"award-number":["03\u2013001\u20132022\u20130157"]}],"id":[{"id":"10.13039\/501100002996","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neuroimaging"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Previous studies have identified hemispheric asymmetries in cerebral blood flow and volume, favoring the left hemisphere. Accordingly, we hypothesized that arteries on the left side of the circle of Willis (CoW) are larger than on the right. We compared artery diameters between the hemispheres.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Cranial time\u2010of\u2010flight magnetic resonance angiography scans of 1052 participants from a population\u2010based cohort were assessed. Diameters of major CoW arteries (&gt; 1.2\u00a0mm) were measured using a semiautomatic tool (mean \u00b1 standard deviation) and compared between the left and right hemisphere using a paired\u2010samples\n                      <jats:italic>t<\/jats:italic>\n                      \u2010test. As the posterior communicating arteries (Pcom) are often small and non\u2010normally distributed, they were measured manually, categorized as \u201cpresent\u201d (\u2265 1\u00a0mm) or \u201caplastic\/hypoplastic\u201d (&lt; 1\u00a0mm), and compared using odds ratios (OR) with 95% confidence intervals (CI).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The A2 segment of the anterior cerebral artery was smaller on the left than on the right (1.97 \u00b1 0.21\u00a0mm vs. 2.01 \u00b1 0.22\u00a0mm;\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001), while the vertebral artery (2.36 \u00b1 0.44\u00a0mm vs. 2.25 \u00b1 0.41\u00a0mm;\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001) and P1 segment of the posterior cerebral artery (2.01 \u00b1 0.28\u00a0mm vs. 1.98 \u00b1 0.29\u00a0mm;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.001) were larger on the left. The Pcom was less frequently present on the left (26.7%) than on the right (33.4%; OR 0.73, 95% CI 0.60\u22120.88). No left\u2013right differences were found for the A1 segment, M1 segment of the middle cerebral artery, and internal carotid artery.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We found that some vessels were larger in the left hemisphere, whereas others were smaller. Future studies should investigate underlying mechanisms driving these specific asymmetries.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jon.70126","type":"journal-article","created":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T09:11:21Z","timestamp":1770196281000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Quantitative MRI Evaluation of Hemispheric Asymmetry in Circle of Willis Artery Diameters"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-1118-5223","authenticated-orcid":false,"given":"Stijn J.","family":"Stoutjesdijk","sequence":"first","affiliation":[{"name":"Department of Neurology and Neurosurgery University Medical Center Utrecht Brain Center University Medical Center Utrecht Utrecht University  Utrecht Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9271-6219","authenticated-orcid":false,"given":"Phebe J.","family":"Groenheide","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurosurgery University Medical Center Utrecht Brain Center University Medical Center Utrecht Utrecht University  Utrecht Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iris N.","family":"Vos","sequence":"additional","affiliation":[{"name":"Image Sciences Institute University Medical Center Utrecht  Utrecht Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robin","family":"B\u00fclow","sequence":"additional","affiliation":[{"name":"Institute For Diagnostic Radiology and Neuroradiology University Medicine Ernst Moritz Arndt University Greifswald  Greifswald Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birgitta K.","family":"Velthuis","sequence":"additional","affiliation":[{"name":"Department of Radiology University Medical Center Utrecht  Utrecht Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ynte M.","family":"Ruigrok","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurosurgery University Medical Center Utrecht Brain Center University Medical Center Utrecht Utrecht University  Utrecht Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,4]]},"reference":[{"key":"e_1_2_8_2_1","volume-title":"Neuroscience","author":"Purves D.","year":"2001"},{"key":"e_1_2_8_3_1","first-page":"223","article-title":"Magnetic Resonance Angiographic Evaluation of Circle of Willis in General Population: A Morphologic Study in 507 Cases","volume":"29","author":"Chen H. 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