{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T19:57:11Z","timestamp":1772999831456,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T00:00:00Z","timestamp":1770940800000},"content-version":"vor","delay-in-days":43,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003748","name":"Svenska S\u00e4llskapet f\u00f6r Medicinsk Forskning","doi-asserted-by":"publisher","award":["Big grant"],"award-info":[{"award-number":["Big grant"]}],"id":[{"id":"10.13039\/501100003748","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003748","name":"Svenska S\u00e4llskapet f\u00f6r Medicinsk Forskning","doi-asserted-by":"publisher","award":["SG\u201022\u20100192\u2010H\u201001"],"award-info":[{"award-number":["SG\u201022\u20100192\u2010H\u201001"]}],"id":[{"id":"10.13039\/501100003748","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003514","name":"Kommunfullm\u00e4ktige, Stockholms Stad","doi-asserted-by":"publisher","award":["ALF Medicine grants"],"award-info":[{"award-number":["ALF Medicine grants"]}],"id":[{"id":"10.13039\/501100003514","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001239","name":"Merck Institute for Science Education","doi-asserted-by":"publisher","award":["Grant for Multiple Sclerosis Innovation award"],"award-info":[{"award-number":["Grant for Multiple Sclerosis Innovation award"]}],"id":[{"id":"10.13039\/100001239","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008599","name":"Alzheimerfonden","doi-asserted-by":"publisher","award":["CIMED junior grant"],"award-info":[{"award-number":["CIMED junior grant"]}],"id":[{"id":"10.13039\/501100008599","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neuroimaging"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Purpose<\/jats:title>\n                    <jats:p>Recent MRI developments have allowed for in vivo myelin imaging in clinically feasible time frames. This retrospective study aimed to evaluate the ability of the Rapid Estimation of Myelin for Diagnostic Imaging (REMyDI) technique in monitoring longitudinal myelin changes and brain atrophy in persons with multiple sclerosis (pwMS) undergoing treatment with rituximab or autologous hematopoietic stem cell transplantation (aHSCT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Between May 2017 and January 2022, 62 pwMS treated with either rituximab (\n                      <jats:italic>n<\/jats:italic>\n                      = 25) or aHSCT (\n                      <jats:italic>n<\/jats:italic>\n                      = 37) underwent brain MRI scans at three time points. A 3 Tesla brain MRI was performed, including 3D T1\u2010weighted imaging, 3D T2\u2010weighted fluid\u2010attenuated inversion recovery imaging, and 2D multi\u2010dynamic multi\u2010echo imaging for REMyDI and brain volumetrics. Longitudinal changes in imaging parameters and associations with the Expanded Disability Status Scale and Symbol Digit Modalities Test were analyzed using mixed\u2010effects models.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The rituximab group exhibited increases in whole\u2010brain myelin (+0.25 mL per year), cortical myelin (+0.11 mL per year), and myelin in normal\u2010appearing deep gray matter (NADGM) (+0.02 mL per year). In contrast, these measures were stable or declined in the aHSCT group. Brain parenchymal fraction showed a larger reduction in the rituximab group (\u22120.68% per year) compared to the aHSCT group (\u22120.24% per year). Myelin\u2010related imaging measures showed positive but nonsignificant associations with clinical parameters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>REMyDI enables longitudinal assessment of myelin\u2010related metrics in vivo, which complements conventional brain volumetrics and is suitable for monitoring treatment responses in MS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jon.70128","type":"journal-article","created":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T14:11:15Z","timestamp":1770991875000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Rapid Estimation of Myelin for Diagnostic Imaging and Quantification of Therapy Responses in Multiple 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