{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T12:29:55Z","timestamp":1777984195526,"version":"3.51.4"},"reference-count":66,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T00:00:00Z","timestamp":1771632000000},"content-version":"vor","delay-in-days":51,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["LA 3567\/2\u20101"],"award-info":[{"award-number":["LA 3567\/2\u20101"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["BI 1254\/9\u20101"],"award-info":[{"award-number":["BI 1254\/9\u20101"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neuroimaging"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Purpose<\/jats:title>\n                    <jats:p>Resting state functional connectivity can be measured using resting state functional MRI (fMRI), but also task\u2010dependent fMRI in blocked designs. The latter has been demonstrated in healthy participants but not yet validated in clinical cohorts. Since functional connectivity of resting state networks (e.g., default mode network [DMN] and somatomotor network [SMN]) is altered in people with epilepsy, and the impact of the disease on the quality of the intermittent resting state data is unclear, we aimed to validate the method using a clinical fMRI in people with epilepsy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We compared functional connectivity derived from a standard resting state with rest periods of a clinical language fMRI (intermittent resting state) of 92 people with focal epilepsy. Both methods were analyzed across different aspects of functional connectivity: topography, within\u2010network connectivity, and group\u2010level comparisons. Therefore, we conducted independent component analyses (ICAs), similarity\u2010, regions of interest (ROI)\u2010to\u2010ROI\u2010, and second\u2010level seed\u2010based analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Results indicated similar ICA\u2010derived topography of DMN and SMN from both methods. Within\u2010network connectivity also yielded comparable results. Seed\u2010based analyses of left and right hippocampal connectivity in people with left and right temporal lobe epilepsy also revealed analogous results, with minor restrictions in right hippocampal connectivity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The intermittent resting state method produces highly similar results to a standard resting state method in people with epilepsy across different aspects of functional connectivity. It is, therefore, an efficient approach to gain insights into functional connectivity networks in a clinical cohort without performing an additional resting state fMRI.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jon.70129","type":"journal-article","created":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T08:49:48Z","timestamp":1771663788000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Default Mode Network Resting State Connectivity Derived From Task\u2010Based fMRI: A Validation Study in People With Epilepsy"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-9532-6786","authenticated-orcid":false,"given":"Lea","family":"Wemheuer","sequence":"first","affiliation":[{"name":"Medical School OWL, Clinical Neuropsychology and Epilepsy Research Bielefeld University  Bielefeld Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Doll","sequence":"additional","affiliation":[{"name":"Medical School OWL, Bethel Epilepsy Center, Department of Epileptology, Krankenhaus Mara Bielefeld University  Bielefeld Germany"},{"name":"Department of Psychology, Affective Neuropsychology Bielefeld University  Bielefeld Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Wegrzyn","sequence":"additional","affiliation":[{"name":"Department of Psychology, Affective Neuropsychology Bielefeld University  Bielefeld Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Mertens","sequence":"additional","affiliation":[{"name":"Bethel Epilepsy Center, MRI\u2010Department, Krankenhaus Mara Society for Epilepsy Research  Bielefeld Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johanna","family":"Kissler","sequence":"additional","affiliation":[{"name":"Department of Psychology, Affective Neuropsychology Bielefeld University  Bielefeld Germany"},{"name":"Center for Cognitive Interaction Technology (CITEC) Bielefeld University  Bielefeld Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian G.","family":"Bien","sequence":"additional","affiliation":[{"name":"Medical School OWL, Bethel Epilepsy Center, Department of Epileptology, Krankenhaus Mara Bielefeld University  Bielefeld Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Friedrich G.","family":"Woermann","sequence":"additional","affiliation":[{"name":"Medical School OWL, Bethel Epilepsy Center, Department of Epileptology, Krankenhaus Mara Bielefeld University  Bielefeld Germany"},{"name":"Bethel Epilepsy Center, MRI\u2010Department, Krankenhaus Mara Society for Epilepsy Research  Bielefeld Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip","family":"Grewe","sequence":"additional","affiliation":[{"name":"Medical School OWL, Clinical Neuropsychology and Epilepsy Research Bielefeld University  Bielefeld Germany"},{"name":"Medical School OWL, Medical Psychology Bielefeld University  Bielefeld Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,21]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-009-0208-6"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/1971400917697342"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2010.03.008"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1993.4"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2005.1634"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0601417103"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.98.2.676"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0135058100"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1440.011"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-neuro-071013-014030"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0504136102"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.24648"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.11.051"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2023.1238888"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/jon.12500"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0042862"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/4198430"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.12400"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2017.09.001"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.21076"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2012.03464.x"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.3171\/2018.7.PEDS18162"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22628"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.3171\/2011.1.JNS10482"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12264-012-1255-1"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.12098"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.12936"},{"key":"e_1_2_8_29_1","article-title":"A Machine Learning Model to Predict Seizure Susceptibility From Resting\u2010State fMRI Connectivity","volume":"2019","author":"Garner R.","year":"2019","journal-title":"Spring Simulation Conference"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2011.03191.x"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X19666210325130624"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nic.2017.06.002"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2021.102723"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2022.877956"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2020.102336"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.13646"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000078815.03224.57"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/epi4.12881"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2025.103784"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-018-0235-4"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.3389\/fninf.2014.00014"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.04.042"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1089\/brain.2012.0073"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.56441\/hilbertpress.2246.5840"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0905267106"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00338.2011"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2019.106523"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2020.106449"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2014.09.023"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.3171\/2022.1.JNS212031"},{"key":"e_1_2_8_51_1","first-page":"66","article-title":"Asymmetrical Hippocampal Connectivity in Mesial Temporal Lobe Epilepsy: Evidence From Resting State fMRI","volume":"11","author":"Pereira F. R. S.","year":"2010","journal-title":"BMC Neuroscience [Electronic Resource]"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1177\/1073858412440596"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0900234106"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2011.03.072"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2016.05.051"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2668-18.2019"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0007198"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0218358"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-78579-6"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2012.07.019"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2014.03.020"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2017.00249"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2019.07.066"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2013.0526"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-013-1304-2"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.31887\/DCNS.2008.10.1\/hbeck"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.17233"}],"container-title":["Journal of Neuroimaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jon.70129","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jon.70129","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jon.70129","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T17:23:35Z","timestamp":1772990615000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jon.70129"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":66,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1111\/jon.70129"],"URL":"https:\/\/doi.org\/10.1111\/jon.70129","archive":["Portico"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.31234\/osf.io\/6uvs9_v1","asserted-by":"object"}]},"ISSN":["1051-2284","1552-6569"],"issn-type":[{"value":"1051-2284","type":"print"},{"value":"1552-6569","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-10-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70129"}}