{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T02:45:37Z","timestamp":1777862737555,"version":"3.51.4"},"reference-count":47,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T00:00:00Z","timestamp":1774224000000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100009797","name":"Barrow Neurological Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009797","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neuroimaging"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Facial nerve (CN VII) diffusion MR tractography is considered as a useful adjunct in pre\u2010operative planning prior to vestibular schwannoma (VS) resection, especially in larger (Koos Grade III\/IV) tumors. Since 2016, several systematic reviews have investigated the clinical value of CN VII tractography in VS, and all reported a \u201csuccess rate\u201d of at least 87% for predicting the pre\u2010operative CN VII position. Yet in clinical practice, CN VII tractography has not yet been widely adopted into routine clinical practice. We suspected that underlying methodology and reporting metrics for existing tractography algorithms may be overestimating success rate. This motivated us to revisit the literature from a different perspective to unravel the caveats and nuances behind this technology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We screened all published works on PubMed related to pre\u2010operative CN VII tractography in VS. Twenty\u2010two studies were reviewed in detail.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We observed a strikingly high heterogeneity in tractography protocols in all domains of the tractography acquisition and analysis pipeline across studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings suggest that the reliability and reproducibility of CN VII tractography in large VS has been overestimated. We believe that employing standardized reporting metrics, including sensitivity, true predictive value, and false discovery rate, would increase the transparency of benchmarking over other commonly reported metrics (\u201csuccess rate\u201d or \u201cconcordance rate\u201d). In addition, ongoing research should aim to systematically investigate and improve each step in the acquisition and analysis pipeline for CN VII tractography in VS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jon.70131","type":"journal-article","created":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T04:24:50Z","timestamp":1774326290000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Facial Nerve Tractography of Vestibular Schwannomas: A Systematic Review of MR Acquisition and Analysis Pipelines"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0787-9236","authenticated-orcid":false,"given":"Yunjia","family":"Ni","sequence":"first","affiliation":[{"name":"Barrow Neuroimaging Innovation Center Department of Translational Neuroscience Barrow Neurological Institute St Joseph's Hospital and Medical Center  Phoenix Arizona USA"},{"name":"Interdisciplinary Graduate Program in Neuroscience School of Life Sciences Arizona State University  Tempe Arizona USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shawn M.","family":"Stevens","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology and Skull Base Surgery Barrow Neurological Institute St Joseph's Hospital and Medical Center  Phoenix Arizona USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Trenton","family":"House","sequence":"additional","affiliation":[{"name":"University of Arizona College of Medicine  Phoenix Arizona USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashton Huppert","family":"Steed","sequence":"additional","affiliation":[{"name":"University of Arizona College of Medicine  Phoenix Arizona USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alma","family":"Jukic","sequence":"additional","affiliation":[{"name":"University of Arizona College of Medicine  Phoenix Arizona USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Parvathy","family":"Hareesh","sequence":"additional","affiliation":[{"name":"Barrow Neuroimaging Innovation Center Department of Translational Neuroscience Barrow Neurological Institute St Joseph's Hospital and Medical Center  Phoenix Arizona USA"},{"name":"School of Biological and Health Systems Engineering Arizona State University  Tempe Arizona USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony M.","family":"Asher","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Barrow Neurological Institute St Joseph's Hospital and Medical Center  Phoenix Arizona USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaith K.","family":"Almefty","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Barrow Neurological Institute St Joseph's Hospital and Medical Center  Phoenix Arizona USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kris A.","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Barrow Neurological Institute St Joseph's Hospital and Medical Center  Phoenix Arizona USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Randall W.","family":"Porter","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Barrow Neurological Institute St Joseph's Hospital and Medical Center  Phoenix Arizona USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael T.","family":"Lawton","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Barrow Neurological Institute St Joseph's Hospital and Medical Center  Phoenix Arizona USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard D.","family":"Dortch","sequence":"additional","affiliation":[{"name":"Barrow Neuroimaging Innovation Center Department of Translational Neuroscience Barrow Neurological Institute St Joseph's Hospital and Medical Center  Phoenix Arizona USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,3,23]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1055\/b000000751"},{"issue":"5","key":"e_1_2_9_3_1","doi-asserted-by":"crossref","first-page":"v1","DOI":"10.1093\/neuonc\/noac202","article-title":"CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2015\u20132019","volume":"24","author":"Ostrom Q. 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