{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T17:50:28Z","timestamp":1783360228039,"version":"3.54.6"},"reference-count":44,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:00:00Z","timestamp":1773014400000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["153005"],"award-info":[{"award-number":["153005"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["W81XWH19\u20101\u20100486"],"award-info":[{"award-number":["W81XWH19\u20101\u20100486"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neuroimaging"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Recent studies suggest that disruptions of the blood\u2013cerebrospinal fluid (CSF) barrier within the choroid plexus (ChP) may contribute to multiple sclerosis (MS) pathogenesis. We investigated the relationship between a quantitative marker of ChP enhancement and markers of focal and diffuse brain tissue injury in MS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A group of 34 MS participants and 21 healthy participants underwent 7T MRI including magnetization prepared 2 rapid acquisition gradient echoes (MP2RAGE) and fluid attenuated inversion recovery (FLAIR) acquisitions. The MS group received contrast, and delta T1 (\u0394T1) maps were computed to assess enhancement. ChP, white matter lesions (WML), normal\u2010appearing white matter (NAWM), and gray matter (GM) were segmented. Pre\u2010contrast quantitative T1 (qT1) values were compared between groups, and linear regression with mean ChP \u0394T1 was performed for WML volume and pre\u2010gadolinium (Gd) mean qT1 of WML, NAWM, and GM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Mean qT1 of ChP, NAWM, and GM, as well as ChP volume, were higher in MS compared to controls (\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001). ChP \u0394T1 was significantly associated with pre\u2010Gd qT1 of NAWM (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      = 0.20,\n                      <jats:italic>\n                        R\n                        <jats:sup>2<\/jats:sup>\n                      <\/jats:italic>\n                      = 0.54,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001) and GM (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      = 0.18,\n                      <jats:italic>\n                        R\n                        <jats:sup>2<\/jats:sup>\n                      <\/jats:italic>\n                      = 0.49,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001), but not WML volume (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.3) or WML qT1 (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The association between ChP enhancement and diffuse tissue injury, together with elevated qT1 values and ChP volumes in MS, supports a mechanism of brain injury involving CSF\u2010mediated toxicity distinct from classic lesion pathology in MS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jon.70132","type":"journal-article","created":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T05:19:12Z","timestamp":1773119952000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Quantitative Choroid Plexus Gadolinium Enhancement Is Related to Diffuse Brain Tissue Injury in Multiple Sclerosis"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3601-9497","authenticated-orcid":false,"given":"Sneha","family":"Senthil","sequence":"first","affiliation":[{"name":"McConnell Brain Imaging Centre, Montreal Neurological Institute\u2010Hospital, McGill University  Montreal Quebec Canada"},{"name":"Department of Neurology and Neurosurgery McGill University  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"Tagge","sequence":"additional","affiliation":[{"name":"McConnell Brain Imaging Centre, Montreal Neurological Institute\u2010Hospital, McGill University  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dumitru","family":"Fetco","sequence":"additional","affiliation":[{"name":"McConnell Brain Imaging Centre, Montreal Neurological Institute\u2010Hospital, McGill University  Montreal Quebec Canada"},{"name":"NeuroRx Research  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng Hsun","family":"Hsieh","sequence":"additional","affiliation":[{"name":"McConnell Brain Imaging Centre, Montreal Neurological Institute\u2010Hospital, McGill University  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haz\u2010Edine","family":"Assemlal","sequence":"additional","affiliation":[{"name":"McConnell Brain Imaging Centre, Montreal Neurological Institute\u2010Hospital, McGill University  Montreal Quebec Canada"},{"name":"NeuroRx Research  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahra","family":"Karimaghaloo","sequence":"additional","affiliation":[{"name":"McConnell Brain Imaging Centre, Montreal Neurological Institute\u2010Hospital, McGill University  Montreal Quebec Canada"},{"name":"NeuroRx Research  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Fetco","sequence":"additional","affiliation":[{"name":"NeuroRx Research  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. 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