{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T11:23:19Z","timestamp":1787656999225,"version":"build-2736575974"},"reference-count":42,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T00:00:00Z","timestamp":1786406400000},"content-version":"vor","delay-in-days":41,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neuroimaging"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Purpose<\/jats:title>\n                    <jats:p>Zotarolimus\u2010eluting stents (ZES) are increasingly used off\u2010label for intracranial atherosclerotic disease (ICAD), yet foundational preclinical data evaluating procedural delivery and short\u2010term vascular safety in cerebral anatomy is sparse. We evaluated the procedural feasibility and 30\u2010day clinical safety of the Onyx Frontier ZES in a canine intracranial model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In a prospective study, 12 healthy canines on dual antiplatelet therapy underwent basilar artery implantation of a 2.0 \u00d7 8.0\u00a0mm Onyx Frontier ZES. Vertebral artery tortuosity was angiographically graded as Type I (mild), II (moderate), or III (severe). Endpoints focused on procedural success and 30\u2010day clinical safety, monitored via angiography, serial neurological examinations, and clinical pathology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Technical success was 100% (12\/12) despite challenging anatomy (mean basilar artery diameter: 1.39\u00a0mm). Tortuosity distribution was 33.3% Type I, 58.3% Type II, and 8.3% Type III. Post\u2010deployment angiographic narrowing consistent with transient vasospasm was observed in 7\/12 animals, without flow limitation; with only one requiring intra\u2010arterial verapamil for resolution. One instance (8.3%) of self\u2010limiting contrast extravasation occurred at the distal basilar artery without long\u2010term sequelae. At 30 days, there was 0% mortality and no procedure\u2010related neurological adverse events. Serial clinical pathology panels demonstrated an absence of systemic organ toxicity or sustained systemic inflammation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Implantation of the Onyx Frontier ZES is highly feasible in sub\u20102\u00a0mm, tortuous intracranial vessels. The platform demonstrated an excellent 30\u2010day clinical safety profile, providing essential procedural and early clinical data to support future integrated regulatory evaluations for ICAD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jon.70141","type":"journal-article","created":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T11:40:02Z","timestamp":1786448402000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Preclinical Evaluation of a Zotarolimus\u2010Eluting Stent for Intracranial Application: A 30\u2010Day Procedural Feasibility and Clinical Observation Canine Study"],"prefix":"10.1111","volume":"36","author":[{"given":"Ibrahim A.","family":"Bhatti","sequence":"first","affiliation":[{"name":"Department of Neurology Baylor University Medical Center  Dallas Texas USA"},{"name":"Zeenat Qureshi Stroke Institute and Department of Neurology University of Missouri  Columbia Missouri 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