{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,3,27]],"date-time":"2024-03-27T13:56:13Z","timestamp":1711547773319},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,2,4]],"date-time":"2016-02-04T00:00:00Z","timestamp":1454544000000},"content-version":"vor","delay-in-days":8069,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neuroimaging"],"published-print":{"date-parts":[[1994,1]]},"abstract":"<jats:p>The chemical characteristics of 10 neoplastic and 11 infectious brain masses were studied by in vivo <jats:sup>1<\/jats:sup>H magnetic resonance spectroscopy. In tumors, peak height ratios of <jats:italic>n<\/jats:italic>\u2010acetyl\u2010L\u2010aspartate to choline were decreased compared to those in normal brain tissue and infectious masses (<jats:italic>p<\/jats:italic> &lt; 0.02), but the ratios in normal brains and those with infections did not differ. <jats:italic>N<\/jats:italic>\u2010acetyl\u2010L\u2010aspartate\u2014to\u2010creatine\/phosphocreatine ratios were significantly lower in infectious masses and tumors compared to normal brain tissue (<jats:italic>p<\/jats:italic> = 0.003). However, in progressive multifocal leukoencephalopathy, <jats:italic>N<\/jats:italic>\u2010acetyl\u2010L\u2010aspartate appeared relatively unchanged. Lactate was greater than choline in 9 of 11 brains with infection, 0 of 14 control brains, and 1 of 10 tumors. Lactate\u2010to\u2010choline ratios were significantly elevated in infectious masses compared with tumors (<jats:italic>p<\/jats:italic> &lt; 0.01). <jats:sup>1<\/jats:sup>H magnetic resonance spectroscopy is promising for the noninvasive diagnosis of focal brain masses.<\/jats:p>","DOI":"10.1111\/jon19944123","type":"journal-article","created":{"date-parts":[[2016,2,8]],"date-time":"2016-02-08T10:35:11Z","timestamp":1454927711000},"page":"23-28","source":"Crossref","is-referenced-by-count":13,"title":["In Vivo Proton Spectroscopy of Intracranial Infections and Neoplasms"],"prefix":"10.1111","volume":"4","author":[{"given":"Nelson T","family":"Yamagata","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce 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