{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T04:30:15Z","timestamp":1785817815343,"version":"3.56.0"},"reference-count":11,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,2,4]],"date-time":"2016-02-04T00:00:00Z","timestamp":1454544000000},"content-version":"vor","delay-in-days":7431,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neuroimaging"],"published-print":{"date-parts":[[1995,10]]},"abstract":"<jats:p>Hyperventilation results in a fall 1n carbon dioxide concentration, a fall in cerebral blood flow, and slowing of activity on the electroencephalogram. The temporal relationship and duration of these responses are uncertain, and were investigated using Simultaneous monitoring of cerebral blood flow velocity and of the electroencephalograph, with end\u2010tidal carbon dioxide monitoring. Sixteen patients and 9 normal volunteers were studied. Cerebral blood flow velocity in the middle cerebral artery was measured using transer anial Doppler sonography during 3 minutes of hyperventilation and during a 3\u2010minute recovery penod Electroencephalographic recordings were rated by both visual score and measurement of the dominant posterior frequency. End\u2010tidal expired carbon dioxide tension was monitored during the same hyperventilation protocol in the volunteers. Flow velocity fell rapidly during act1ve hyperventilation. Electroencephalographic slowing closely correlated with the decrease in flow velocity (r = 0.86), but lagged behind t. In healthy volunteers capnographic records showed a very tight coupling between end\u2010tidal carbon dioxide concentration and flow velocity (r = 0.94). Three mmutes after hyperventilation, carbon dioxide concentration, cerebral blood flow velocity, and electroencephalographic activity were still not back to the resting state. The fall in both cerebral blood flow velocity and carbon dioxide concentration are related to but precede electroencephalographic slowing. The abnormalities persist for at least 3 minutes after hyperventilation and this must be taken into account in clinical electroencephalography. Transcranial Doppler sonography is well suited to monitoring short\u2010term changes in the cerebral circulation.<\/jats:p>","DOI":"10.1111\/jon199554209","type":"journal-article","created":{"date-parts":[[2016,2,8]],"date-time":"2016-02-08T10:34:44Z","timestamp":1454927684000},"page":"209-211","source":"Crossref","is-referenced-by-count":12,"title":["Changes in Cerebral Blood Flow as Monitored by Transcranial Doppler During Voluntary Hyperventilation and Their Effect on the Electroencephalogram"],"prefix":"10.1111","volume":"5","author":[{"given":"J.","family":"Duarte","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Markus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. J. G.","family":"Harrison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,2,4]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI101680"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1968.24.1.60"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1965.00460280080008"},{"key":"e_1_2_1_5_1","first-page":"304","article-title":"Alterations in the EEG of awake man produced by hyperventilation: effects of 100% oxygen at 3 atmospheres (absolute) pressure","volume":"16","author":"Reivich M","year":"1966","journal-title":"Neurology"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910100204"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004424-196701000-00016"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.17.5.913"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.19.8.963"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1992.20"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.23.2.171"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.23.11.1680"}],"container-title":["Journal of Neuroimaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjon199554209","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjon199554209","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jon199554209","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T19:48:06Z","timestamp":1698349686000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jon199554209"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,10]]},"references-count":11,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1995,10]]}},"alternative-id":["10.1111\/jon199554209"],"URL":"https:\/\/doi.org\/10.1111\/jon199554209","archive":["Portico"],"relation":{},"ISSN":["1051-2284","1552-6569"],"issn-type":[{"value":"1051-2284","type":"print"},{"value":"1552-6569","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,10]]}}}