{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T06:21:55Z","timestamp":1780381315451,"version":"3.54.1"},"reference-count":5,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,2,4]],"date-time":"2016-02-04T00:00:00Z","timestamp":1454544000000},"content-version":"vor","delay-in-days":7248,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neuroimaging"],"published-print":{"date-parts":[[1996,4]]},"abstract":"<jats:p>Because demyelinating disease of the brain occasionally presents with large ring\u2010enhancing lesions on computed tomography (CT) scans and magnetic resonance images (MRis), the authors sought to determine whether the ring pattern differed from that found in other common brain lesions with ring enhancement. Published MRI and CT scans of patients with adrenoleukodystrophy (23), and multiple sclerosis or similar demyelinating disorders (21), as well as a variety of tumors (44) and infections (44) matched to the demyelinating lesions by year of publication, in which ring enhancement was evident, were photographed. Photographs without diagnostic identification were presented randomly to two independent observers. The observers rated the contrast enhancement pattern as (1) open ring, with enhancement in the border of the lesion abutting the white matter; (2) closed ring; or (3) uncertain. For all diagnostically certain cases (n = 112), interrater agreement was excellent (\u03ba = 0.75). As an average of the two reviewers, scans for 11 of 132 cases were read as uncertain; 89% of adrenoleukodystrophy cases, 41% of the multiple sclerosis cases, 3% of tumors, and 9% of infections were classified as having the open\u2010ring pattern. Overall, 66% of demyelinating lesions had an open\u2010ring pattern compared with 7% of the nondemyelinating lesions (\u03c7<jats:sup>2<\/jats:sup> = 41.2, <jats:italic>p<\/jats:italic> &lt; 0.0001 ). An open\u2010ring pattern of enhancement is more likely to be associated with demyelinating lesions than with nondemyelinating lesions .<\/jats:p>","DOI":"10.1111\/jon199662104","type":"journal-article","created":{"date-parts":[[2016,2,8]],"date-time":"2016-02-08T10:31:50Z","timestamp":1454927510000},"page":"104-107","source":"Crossref","is-referenced-by-count":60,"title":["The Open Ring A New Imaging Sign in Demyelinating Disease"],"prefix":"10.1111","volume":"6","author":[{"given":"Joseph C.","family":"Masdeu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Moreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunil","family":"Trasi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Visintainer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rossella","family":"Cavaliere","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Grundman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,2,4]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jon199332143"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1227\/00006123-198708000-00023","article-title":"Multiple sclerosis plaque simulating cerebral tumor: case report and review of the literature","volume":"21","author":"Mastrostefano R","year":"1987","journal-title":"Neurosurgery"},{"key":"e_1_2_1_4_1","first-page":"469","article-title":"Myelinoclastic diffuse and transitional sclerosis","author":"Poser CM","year":"1970","journal-title":"Handbook of clinical neurology, vol 9. Multiple sclerosis and other demyelinating diseases"},{"key":"e_1_2_1_5_1","first-page":"419","article-title":"Myelinoclastic diffuse sclerosis","author":"Poser CM","year":"1985","journal-title":"Handbook of clinical neurology, vol 3 (47). Demyelinating diseases"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410330105"}],"container-title":["Journal of Neuroimaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjon199662104","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjon199662104","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jon199662104","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T23:50:02Z","timestamp":1698364202000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jon199662104"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,4]]},"references-count":5,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1996,4]]}},"alternative-id":["10.1111\/jon199662104"],"URL":"https:\/\/doi.org\/10.1111\/jon199662104","archive":["Portico"],"relation":{},"ISSN":["1051-2284","1552-6569"],"issn-type":[{"value":"1051-2284","type":"print"},{"value":"1552-6569","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,4]]}}}