{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T20:59:09Z","timestamp":1771016349870,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,2,4]],"date-time":"2016-02-04T00:00:00Z","timestamp":1454544000000},"content-version":"vor","delay-in-days":7248,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neuroimaging"],"published-print":{"date-parts":[[1996,4]]},"abstract":"<jats:p>Cerebral vasodilatory testing provides an important measure of both the hemodynamic significance of arterial occlusive disease and the adequacy of collateral pathways . This study measured the extracranial intravascular volume flow rate response to acetazolamide using phase\u2010contrast magnetic resonance angiography. From 10 patients with unilateral carotid transient ischemic attacks (TIAs), a total of 18 extracranial carotid arteries (10 symptomatic, 8 asymptomatic, 2 occluded) and 19 extracranial vertebral arteries were studied . Patients were free of large\u2010vessel intracranial stenoses, evident areas of ischemic infarction, evident areas of nonspecific white matter change, and hemodynamic or lowflow induction of TIA symptomatology. Asymptomatic carotid volume flow rates rose from 1 51 \u00b1 19 (standard error of mean) to 220 \u00b1 26 ml\/min while symptomatic flow rates rose from 106 \u00b1 22 to 145 \u00b1 25 ml\/min . Dominant vertebral volume flow rates rose from 128 \u00b1 23 to 160 \u00b1 22 ml\/min while nondominant rates rose from 40 \u00b1 12 to 61 \u00b1 15 ml\/min. Carotid volume flow rates were inversely proportional to percent stenosis for both baseline (r = 0 .51, p &lt; 0 .02) and acetazolamide (r = 0.81, p &lt; 0 .001) data . Baseline\u2010plus\u2010acetazolamide volume flow rate techniques safely measure intravascular vasodilatory responses. Intracranial measurement techniques are being developed to further study cerebrovascular reserve using phase\u2010contrast magnetic resonance angiography .<\/jats:p>","DOI":"10.1111\/jon199662126","type":"journal-article","created":{"date-parts":[[2016,2,8]],"date-time":"2016-02-08T10:31:50Z","timestamp":1454927510000},"page":"126-130","source":"Crossref","is-referenced-by-count":10,"title":["Extracranial Intravascular Vasodilatory Response to Acetazolamide and Magnetic Resonance"],"prefix":"10.1111","volume":"6","author":[{"given":"Ross L.","family":"Levine","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick A.","family":"Turski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William D.","family":"Turnipseed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Grist","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,2,4]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.25.2.413"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/S1052-5149(25)00110-8","article-title":"Magnetic resonance angiography and stroke: techniques, applications, and limitations","volume":"2","author":"Crosby DL","year":"1992","journal-title":"Neuroimag Clin North Am"},{"key":"e_1_2_1_4_1","first-page":"541","article-title":"MR angi\u2010130 Journal of Neuroimaging Vol & No 2 April1996 ography flow analysis. 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