{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T22:13:44Z","timestamp":1762899224762},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,2,4]],"date-time":"2016-02-04T00:00:00Z","timestamp":1454544000000},"content-version":"vor","delay-in-days":7157,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neuroimaging"],"published-print":{"date-parts":[[1996,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cerebrovascular reserve (CVR) is the potential for cerebral arteriolar dilatation to occur, in response to decreased cerebral perfusion pressure, in order to maintain constant cerebral blood flow. Diminution or absence of CVR is considered a risk factor for stroke. Current methods for determining CVR include singlephoton emission computed tomography, positron emission tomography and transcranial Doppler (TCD) ultrasonography. However, significant advantages could derive from the utilization of magnetic resonance angiography (MRA) based on the concurrent acquisition of hemodynamic information (CVR and collateral flow) with phase\u2012contrast (PC) techniques and vascular morphology with three\u2012dimensional, time\u2012of\u2012flight methods. With a 1.5\u2012T scanner and acetazolamide (AZM), an arteriolar dilator, CVR was determined in 7 normal subjects. Mean flow velocity in the middle cerebral arteries was determined by PC MRA before and after AZM administration. For comparative purposes, mean flow velocities in the same middle cerebral arteries were determined by TCD before and after AZM administration. The mean flow velocities were as follows (mean \u00b1 standard deviation, n = 7): 40 \u00b1 8 (PC MRA) versus 61 \u00b110 cm\/sec (TCD) before AZM treatment and 58 \u00b111 (PC MRA) versus 85 \u00b115 cm\/sec (TCD) after AZM administration. The increase in mean flow velocity (before vs after AZM), that is, the CVR, was 45 \u00b111 % as shown by PC MRA and 39 \u00b1 14% as shown by TCD. Although significant differences were present between the mean flow velocities measured before and those after AZM administration, as determined by PC MRA and TCD, the CVR was not significantly different (45 vs 39%, respectively). These preliminary results suggest that PC MRA may be a method for determining CVR.<\/jats:p>","DOI":"10.1111\/jon199663137","type":"journal-article","created":{"date-parts":[[2016,2,8]],"date-time":"2016-02-08T10:31:58Z","timestamp":1454927518000},"page":"137-143","source":"Crossref","is-referenced-by-count":23,"title":["Phase\u2010Contrast Magnetic Resonance Angiography for the Determination of Cerebrovascular Reserve"],"prefix":"10.1111","volume":"6","author":[{"given":"James T.","family":"Patrick","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph V.","family":"Fritz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John M.","family":"Adamo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paresh","family":"Dandonna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,2,4]]},"reference":[{"key":"e_1_2_1_2_1","volume-title":"1992 Heart and stroke facts","year":"1992"},{"key":"e_1_2_1_3_1","first-page":"14.1","article-title":"Management of medical complications in cerebrovascular disease","author":"Patrick JT","year":"1996","journal-title":"Atlas of cerebrovascular disease"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.19.8.963"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.23.2.171"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800720506"},{"key":"e_1_2_1_7_1","volume-title":"Transcranial Doppler ultrasonography","author":"Babikian VL","year":"1993"},{"key":"e_1_2_1_8_1","volume-title":"Transcranial Doppler","author":"Newell DW","year":"1992"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.20.4.458"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.51.8.1045"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.17.5.913"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.18.6.1025"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.13.2.155"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.18.5.887"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1987.67.4.0525"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1992.20"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.21.9.1306"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.193.1.8090876"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.161.1.8517285"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.1880030504"},{"key":"e_1_2_1_21_1","first-page":"123","article-title":"Blood flow in major cerebral arteries measured by phase-contrast cine MR","volume":"15","author":"Enzmann DR","year":"1994","journal-title":"AJNR"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.181.2.1924799"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI111579"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1159\/000108682"},{"key":"e_1_2_1_25_1","first-page":"41","volume-title":"Transcranial Doppler","author":"Adams RJ","year":"1992"},{"key":"e_1_2_1_26_1","first-page":"29","volume-title":"Transcranial Doppler ultrasonography","author":"DeWitt LD","year":"1993"}],"container-title":["Journal of Neuroimaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjon199663137","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjon199663137","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jon199663137","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T04:45:08Z","timestamp":1698381908000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jon199663137"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,7]]},"references-count":25,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1996,7]]}},"alternative-id":["10.1111\/jon199663137"],"URL":"https:\/\/doi.org\/10.1111\/jon199663137","archive":["Portico"],"relation":{},"ISSN":["1051-2284","1552-6569"],"issn-type":[{"value":"1051-2284","type":"print"},{"value":"1552-6569","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,7]]}}}