{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T15:05:27Z","timestamp":1779894327281,"version":"3.53.1"},"reference-count":15,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,2,4]],"date-time":"2016-02-04T00:00:00Z","timestamp":1454544000000},"content-version":"vor","delay-in-days":7157,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neuroimaging"],"published-print":{"date-parts":[[1996,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The acetazolamide test of cerebrovascular reserve is performed as a two\u2010point transcranial Doppler (TCD) measurement of the flow velocity in the middle cerebral artery (MCA) before and 15 to 20 minutes after injection of the carbonic anhydrase inhibitor. The time course was evaluated by bilateral TCD monitoring over 45 minutes in 51 patients with extracranial carotid artery disease. Twenty\u2010nine patients in Group 1 showed a unilateral and 22 patients in Group 2, a bilateral stenosis of the internal carotid artery (ICA). Thirty\u2010one normal hemispheres in 18 normal subjects provided baseline control values. The most useful parameter for the description of the time course was the integral of the mean flow velocity. In both groups integral of the mean flow velocity was significantly reduced compared to that in normal persons (Group 1:587.2 \u00b1 538.3 cm, p &lt; 0.01; Group 2: 728.9 \u00b1 397.1 cm, p &lt; 0.01; normal persons: 967.8 \u00b1 350.0 cm). The maximal increase of mean flow velocity in a two\u2010point measurement also was significantly lower in the patient groups, but did not reach the same level of significance in Group 2 (Group 1: 19.6 \u00b1 12.3 cm\/sec, p &lt; 0.01; Group 2: 24.2 \u00b1 10.4 cm\/sec, p &lt; 0.05). Thirty\u2010four of 73 hemispheres had reduced integral of the mean flow velocity, but only 29 had a reduced maximal increase. These data indicate that continuous monitoring and evaluation of the time course of the acetazolamide effect provide additional information on cerebrovascular reserve and help to detect an increased number of patients with impaired cerebrovascular reserve.<\/jats:p>","DOI":"10.1111\/jon199663144","type":"journal-article","created":{"date-parts":[[2016,2,8]],"date-time":"2016-02-08T10:31:58Z","timestamp":1454927518000},"page":"144-149","source":"Crossref","is-referenced-by-count":11,"title":["Time Course of the Acetazolamide Effect in Patients with Extracranial Carotid Artery Disease"],"prefix":"10.1111","volume":"6","author":[{"given":"Martin","family":"Stoll","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard F.","family":"Hamann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Volker","family":"Jost","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Urania Argyropulu-Raka","family":"Bompotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Fitridge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Schimrigk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,2,4]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1992.20"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.23.2.171"},{"key":"e_1_2_1_4_1","first-page":"138","article-title":"Assessment of cerebral vasoreactivity and stroke risk using XE, CT acetazolamide challenge","volume":"22","author":"Durham SR","year":"1991","journal-title":"Stroke"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.25.6.1193"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.24.5.670"},{"key":"e_1_2_1_7_1","first-page":"49","article-title":"Assessment of postischemic reperfusion and Diamox activation in stroke using 99mTc-ECD SPECT","volume":"14","author":"Nakagawara J","year":"1994","journal-title":"J Cereb Blood Flow Metab"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/000331978803900504"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.21.9.1306"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.23.6.812"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01772826"},{"key":"e_1_2_1_12_1","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1152\/jappl.1992.73.5.1756","article-title":"Effect of acetazolamide on cerebral blood flow and capillary patency","volume":"73","author":"Frankel HM","year":"1992","journal-title":"J Appl Physiol"},{"key":"e_1_2_1_13_1","first-page":"33","article-title":"Investigation of cerebrovascular reactivity using TCD, evaluation and comparison of different methods","volume":"5","author":"Provinciali L","year":"1989","journal-title":"Funct Neurol"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/jon19966129"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1983.tb07202.x"},{"key":"e_1_2_1_16_1","first-page":"748","article-title":"Reduced rapid vascular autoregulation in patients with reduced cerebral reactivity","volume":"25","author":"Peters P","year":"1994","journal-title":"Stroke"}],"container-title":["Journal of Neuroimaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjon199663144","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjon199663144","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jon199663144","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T04:45:39Z","timestamp":1698381939000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jon199663144"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,7]]},"references-count":15,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1996,7]]}},"alternative-id":["10.1111\/jon199663144"],"URL":"https:\/\/doi.org\/10.1111\/jon199663144","archive":["Portico"],"relation":{},"ISSN":["1051-2284","1552-6569"],"issn-type":[{"value":"1051-2284","type":"print"},{"value":"1552-6569","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,7]]}}}