{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:40:00Z","timestamp":1791330000636,"version":"4.3.1"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,2,4]],"date-time":"2016-02-04T00:00:00Z","timestamp":1454544000000},"content-version":"vor","delay-in-days":6700,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neuroimaging"],"published-print":{"date-parts":[[1997,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To investigate focal hyperintensity in the internal capsule (1C) on magnetic resonance images (MRIs) and its clinical significance, 80 patients with amyotrophic lateral sclerosis (ALS) and 80 sex\u2010 and age\u2010matched normal control subjects were studied. On T2\u2010weighted images, hyperintense foci were found in the posterior part of the posterior limb (PL) of the 1C in 41 (51 %) of 80 control subjects. However, no subject showed increased signal intensities on proton density\u2010weighted images. Hyperintense foci were also observed in the posterior part of the PL of the IC on T2\u2010weighted images in 52 (65%) of 80 ALS patients and on proton density\u2010weighted images in 26 (65%) of 40 ALS patients; the abnormally intense foci were seen at the same anatomical location in the IC as those in the normal control subjects. On postmortem MRI, the abnormally intense foci were found in the posterior part of the PL of the IC in the formalin\u2010 fixed brains from 9 ALS patients. Three normal control subjects did not show signal intensity changes on postmortem MRI. On histological examination of 9 ALS brains, distinct myelin pallor and gliosis were found in the posterior third of the PL of the IC. Proton density\u2010weighted images appear to be useful to distinguish neuropathological changes in the corticospinal tract of ALS patients.<\/jats:p>","DOI":"10.1111\/jon199774208","type":"journal-article","created":{"date-parts":[[2016,2,8]],"date-time":"2016-02-08T10:29:29Z","timestamp":1454927369000},"page":"208-212","source":"Crossref","is-referenced-by-count":44,"title":["Degeneration of the Pyramidal Tracts in Patients with Amyotrophic Lateral Sclerosis"],"prefix":"10.1111","volume":"7","author":[{"given":"Kazuo","family":"Abe,","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harutoshi","family":"Fujimura,","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuo","family":"Kobayashi,","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norihiko","family":"Fujita,","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takehiko","family":"Yanagihara,","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,2,4]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneurpsyc.1940.02280100020002"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.23.4.269"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.33.3.338"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410230424"},{"key":"e_1_2_1_6_1","first-page":"1061","article-title":"MR imaging of compact white matter pathways","volume":"9","author":"Curnes JT","year":"1988","journal-title":"AJNR"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.172.2.2748836"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.43.8.1569"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.191.2.8153321"},{"key":"e_1_2_1_10_1","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/0022-510X(94)90191-0","article-title":"World Federation of Neurology Research Group on Neuromuscular Diseases. 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