{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T02:20:27Z","timestamp":1767666027944},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,2,4]],"date-time":"2016-02-04T00:00:00Z","timestamp":1454544000000},"content-version":"vor","delay-in-days":6608,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neuroimaging"],"published-print":{"date-parts":[[1998,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Transcranial Doppler measurement (TCD) of cerebrovascular reserve (CVR) is usually performed by the C02 test, the acetazolamide test, or the breath\u2013holding test. Since these tests are time\u2013consuming and labor\u2013intensive, alternative methods such as the hand\u2013gripping test are of interest. Twenty\u2013one normal persons and 25 patients with unilateral carotid artery disease were studied. Flow velocity changes in both middle cerebral arteries (MCAs) during bilateral hand gripping were measured by TCD and compared with acetazolamide test results. The increase in MCA mean flow velocity (FVmean) during hand gripping was 18.0 \u00b1 6.3% in normal persons; the increases in the poststenotic MCA were 15.8 \u00b1 9.7% in all patients and 9.4 \u00b1 5.4% in patients with impaired CVR as determined by the acetazolamide test. Only in the group with impaired acetazolamide reactivity was the increase in the poststenotic MCA significantly lower compared to that in controls (p &lt; 0.01 ) and to the contralateral, nonstenotic side (p &lt; 0.01). Nevertheless the FVmean increases in both tests showed a weak, but significant correlation (r = 0.59, p &lt; 0.01) All FVmean increases during hand gripping were significantly (p &lt; 0.01) lower than those during the acetazolamide test. The test appears as a weaker stimulus for MCA blood flow velocity increase than the acetazolamide test. Thus, only a substantial reduction of acetazolamide reactivity leads to a reduced MCA FVmean increase using hand gripping. Although it is highly specific but less sensitive, hand gripping does not appear to be suitable as a screening measure of CVR, but might be useful in addition to standard tests.<\/jats:p>","DOI":"10.1111\/jon19988127","type":"journal-article","created":{"date-parts":[[2016,2,8]],"date-time":"2016-02-08T10:28:07Z","timestamp":1454927287000},"page":"27-31","source":"Crossref","is-referenced-by-count":6,"title":["Hand Gripping and Acetazolamide Effect in Normal Persons and Patients with Carotid Artery Disease"],"prefix":"10.1111","volume":"8","author":[{"given":"Martin","family":"Stoll","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antje","family":"Seidel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus","family":"Schimrigk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerhard F.","family":"Hamann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,2,4]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1982.48.2.467"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410290112"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1515\/JBCPP.1990.1.1-4.191"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1980.43.1.118"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.18.4.771"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.44.10.1910"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.24.11.1673"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1994.77.6.2804"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.21.9.1306"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jon19966129"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jon199663144"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.19.8.963"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.23.5.668"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1004020"},{"key":"e_1_2_1_16_1","first-page":"1132","article-title":"The influence of different techniques of breath holding on the measurement of cerebrovascular reserve in carotid artery disease","volume":"27","author":"Stoll M","year":"1996","journal-title":"Stroke"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1011918"},{"key":"e_1_2_1_18_1","first-page":"197","volume-title":"Statistical methods for research workers","author":"Fischer RA","year":"1954"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.25.11.2117"}],"container-title":["Journal of Neuroimaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjon19988127","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjon19988127","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jon19988127","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T23:52:47Z","timestamp":1698450767000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jon19988127"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,1]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1998,1]]}},"alternative-id":["10.1111\/jon19988127"],"URL":"https:\/\/doi.org\/10.1111\/jon19988127","archive":["Portico"],"relation":{},"ISSN":["1051-2284","1552-6569"],"issn-type":[{"value":"1051-2284","type":"print"},{"value":"1552-6569","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,1]]}}}