{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T07:45:35Z","timestamp":1698651935337},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,2,4]],"date-time":"2016-02-04T00:00:00Z","timestamp":1454544000000},"content-version":"vor","delay-in-days":6153,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neuroimaging"],"published-print":{"date-parts":[[1999,4]]},"abstract":"<jats:p>Orthostasis reduces mean flow velocity (FVmean) in cerebral arteries. This might be used as an alternative provocation test for cerebral hemodynamics in patients with carotid artery disease (CAD). In 21 unilateral CAD patients and 21 controls, FVmean in both middle cerebral arteries (MCA) was measured by transcranial Doppler, together with blood pressure (BP) and heart rate (HR) during a tilt table test. Cerebrovascular reserve (CVR) was measured by an acetazolamide test. In all cases, FVmean dropped to a lower level (controls: 81.9 \u00b1 9.4% of baseline; patients: 84.3 \u00b1 7.9% symptomatic side, 85.6 \u00b1 9.0% contralateral). Impaired CVR patients showed a smaller (p&lt;0.01) decrease (90.6 \u00b1 3.3%) compared to contralateral (84.9 \u00b1 6.0%), to normal CVR patients (81.1 \u00b1 7.8%) and to controls. Heart rate increased in both groups (controls: \u2012 16.6 \u00b1 9.9%, patients+ 10.3 \u00b1 9.9%; <jats:italic>p<\/jats:italic>\u20120.01 ); BP showed no change. Orthostasis induces a decrease of MCA Fvmean as already previously described. This decrease is significantly smaller in patients with impaired CVR. Since BP does not change, some authors explain the lower MCA Fvmean during orthostasis as caused by sympathetic induced vasoconstriction of cerebral resistance vessels. The authors speculate that in impaired CVR\u2010patients autoregulative protection against ischemia might limit vasoconstriction. In combination with standard tests for measurement of CVR, this test might be useful for evaluation of cerebral autoregulation.<\/jats:p>","DOI":"10.1111\/jon199992113","type":"journal-article","created":{"date-parts":[[2016,2,8]],"date-time":"2016-02-08T10:10:10Z","timestamp":1454926210000},"page":"113-117","source":"Crossref","is-referenced-by-count":2,"title":["Orthostasis as a Test for Cerebral Autoregulation in Normal Persons and Patients With Carotid Artery Disease"],"prefix":"10.1111","volume":"9","author":[{"given":"Martin","family":"Stoll","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antje","family":"Seidel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus","family":"Schimrigk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerhard F.","family":"Hamann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,2,4]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-88077-3"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1011958"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1011630"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000108822"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.90.1.298"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.21.9.1306"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.19.8.963"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.15.6.1066"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.39.4.385"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1011918"},{"key":"e_1_2_1_12_1","first-page":"197","volume-title":"Statistical methods for research workers","author":"Fischer RA","year":"1954"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.18.6.1025"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.22.9.1148"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.25.9.1771"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.20.1.45"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.42.3.295"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1995.tb09894.x"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.37.5.550"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.4.2.187"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.26.10.1794"},{"key":"e_1_2_1_22_1","first-page":"451","article-title":"Cerebral hyperperfusion syndrome : an etiology of seizures following carotid endarterectomy","volume":"91","author":"George SM","year":"1993","journal-title":"J Ky Med Assoc"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.2176\/nmc.31.961"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.1992.20"}],"container-title":["Journal of Neuroimaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjon199992113","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjon199992113","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jon199992113","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,29]],"date-time":"2023-10-29T07:20:47Z","timestamp":1698564047000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jon199992113"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,4]]},"references-count":23,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1999,4]]}},"alternative-id":["10.1111\/jon199992113"],"URL":"https:\/\/doi.org\/10.1111\/jon199992113","archive":["Portico"],"relation":{},"ISSN":["1051-2284","1552-6569"],"issn-type":[{"value":"1051-2284","type":"print"},{"value":"1552-6569","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,4]]}}}