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Large vessel cerebral atherosclerosis is usually associated with high levels of lowdensity lipoprotein (LDL) cholesterol, but a low level of high\u2010density lipoprotein (HDL) is also a risk factor for ischemic strokes. The magnitude of increased risk is unclear, particularly with extremely low HDL levels found only in various genetic and inherited disorders. Advanced atherosclerosis developed in the patient in this study, with HDL of 3 mg\/dL, leading to rapidly progressive stroke with a fatal outcome. The disease primarily affected the posterior circulation. The course of this case illustrates that very low HDL may be associated with advanced cerebrovascular atherosclerosis and fatal stroke, and as such should be considered in young individuals with stroke.<\/jats:p>","DOI":"10.1111\/jon2000104233","type":"journal-article","created":{"date-parts":[[2016,2,8]],"date-time":"2016-02-08T10:09:24Z","timestamp":1454926164000},"page":"233-236","source":"Crossref","is-referenced-by-count":2,"title":["Rapidly Progressive Stroke in a Young Adult With Very Low High\u2010Density Lipoprotein Cholesterol"],"prefix":"10.1111","volume":"10","author":[{"given":"Sasa A.","family":"Zivkovic","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oscar L.","family":"Lopez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina","family":"Zaretsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lawrence R.","family":"Wechsler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,2,4]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"373","article-title":"Stroke incidence, prevalence, and survival: secular trends in Rochester, Minnesota, through 1989","volume":"27","author":"Brown RD","year":"1996","journal-title":"Stroke"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.50.4.890"},{"key":"e_1_2_1_4_1","first-page":"18","volume-title":"Toole JF, ed. 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