{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T22:02:23Z","timestamp":1761948143763},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,2,4]],"date-time":"2016-02-04T00:00:00Z","timestamp":1454544000000},"content-version":"vor","delay-in-days":5604,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Neuroimaging"],"published-print":{"date-parts":[[2000,10]]},"abstract":"<jats:p>Previous functional neuroimaging studies performed during transient global amnesia (TGA) have not answered the central question regarding the etiology of TGA. namely: whether the observed hypoperfusion in the mesial temporal lobe structures reflects a primarily ischemic process or whether it represents a secondary phenomenon resulting from locally decreased metabolism. The authors performed Tc 99\u2010m\u2010bicisate brain single photon\u2010emission computed tomography (SPECT) scanning in a 66\u2010year\u2010old man during an episode of TGA, 24 hours after the episode and 3 months after the episode. To the authors' knowledge, this is the only reported study in which a follow\u2010up SPECT scan was performed within 24 hours. The initial study showed bilateral mesial temporal lobe hypoperfusion that partially resolved after 24 hours and returned to normal at 3 months. Resolution of the SPECT scan abnormalities correlated well with resolution of the memory loss. These findings agree with previously reported SPECT, positronemission tomography (PET), and diffusion magnetic resonance imaging (MRI) studies that indicate the mesial temporal lobe structures as the major site of pathology in TGA. The authors suggest that a process causing decreased local metabolism, such as cortical spreading depression, constitutes the primary pathophysiologic mechanism in this case.<\/jats:p>","DOI":"10.1111\/jon2000104238","type":"journal-article","created":{"date-parts":[[2016,2,8]],"date-time":"2016-02-08T10:09:24Z","timestamp":1454926164000},"page":"238-241","source":"Crossref","is-referenced-by-count":30,"title":["Evolution of Temporal Lobe Hypoperfusion in Transient Global Amnesia: A Serial Single Photon Emission Computed Tomography Study"],"prefix":"10.1111","volume":"10","author":[{"given":"Tudor G.","family":"Jovin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard A.","family":"Vitti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leo F.","family":"McCluskey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,2,4]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410430203"},{"key":"e_1_2_1_3_1","first-page":"155","article-title":"Cerebral perfusion during transient global amnesia: findings with HMp AO SPECT","volume":"39","author":"Schmidtke K","year":"1998","journal-title":"J Nucl Med"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.56.12.1327"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.53.4.339"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.61.6.654-a"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003072-199301000-00011"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.24.7.1093"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.41.11.1748"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.56.11.1227"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.63.5.605"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1991.tb04897.x"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.63.3.357"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410430206"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.53.10.834"},{"key":"e_1_2_1_16_1","first-page":"1163","article-title":"High\u2010resolution SPECT to assess hippocampal perfusion in neuropsychiatric diseases","volume":"36","author":"Ohnishi T","year":"1995","journal-title":"J Nucl Med"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.34.7.855"},{"key":"e_1_2_1_18_1","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/BF00208997","article-title":"Noninvasive measurements of regional cerebral blood flow using technetium-99m hexamethylpropylene amine oxime","volume":"20","author":"Matsuda H","year":"1993","journal-title":"Eur J Nucl Med"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3223(89)90106-6"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.26.9.1536"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/117.1.199"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004647-199808000-00013"},{"key":"e_1_2_1_23_1","first-page":"1097","article-title":"Cerebral infarction within six hours of onset: prediction of completed infarction with technetium\u201099m\u2010HMPAO SPECT","volume":"35","author":"Shimosegawa E","year":"1994","journal-title":"J Nucl Med"}],"container-title":["Journal of Neuroimaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjon2000104238","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjon2000104238","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jon2000104238","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,29]],"date-time":"2023-10-29T14:28:06Z","timestamp":1698589686000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jon2000104238"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,10]]},"references-count":22,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2000,10]]}},"alternative-id":["10.1111\/jon2000104238"],"URL":"https:\/\/doi.org\/10.1111\/jon2000104238","archive":["Portico"],"relation":{},"ISSN":["1051-2284","1552-6569"],"issn-type":[{"value":"1051-2284","type":"print"},{"value":"1552-6569","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,10]]}}}