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Twenty\u2010eight healthy and pain\u2010free volunteers, fourteen women and fourteen men participated in this randomized, double\u2010blind and placebo\u2010controlled study. After a screening examination and registration of the baseline pressure\u2013pain threshold (\n                    <jats:styled-content style=\"fixed-case\">PPT<\/jats:styled-content>\n                    ), the first simultaneous bilateral injections of 0\u00b75\u00a0mL acidic saline (9\u00a0mg\u00a0mL\n                    <jats:sup>\u22121<\/jats:sup>\n                    ,\n                    <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content>\n                    3\u00b73) into the masseter muscles were performed. Two days later,\n                    <jats:styled-content style=\"fixed-case\">PPT<\/jats:styled-content>\n                    and pain (\n                    <jats:styled-content style=\"fixed-case\">VAS<\/jats:styled-content>\n                    ) were re\u2010assessed. The masseter muscle was then pre\u2010treated with 0\u00b75\u00a0mL granisetron (Kytril\n                    <jats:sup>\u00ae<\/jats:sup>\n                    1\u00a0mg\u00a0mL\n                    <jats:sup>\u22121<\/jats:sup>\n                    <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content>\n                    5\u00b73) on one side and control substance (isotonic saline, 9\u00a0mg\u00a0mL\n                    <jats:sup>\u22121<\/jats:sup>\n                    <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content>\n                    6) on the contralateral side. Two minutes thereafter a bilateral simultaneous injection of 0\u00b75\u00a0mL acidic saline followed. The evoked pain intensity, pain duration, pain area and\n                    <jats:styled-content style=\"fixed-case\">PPT<\/jats:styled-content>\n                    were assessed. The volunteers returned 1\u00a0week later to re\u2010assess\n                    <jats:styled-content style=\"fixed-case\">VAS<\/jats:styled-content>\n                    and\n                    <jats:styled-content style=\"fixed-case\">PPT<\/jats:styled-content>\n                    . On the side pre\u2010treated with granisetron, the induced pain had significantly lower intensity and shorter duration (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0&lt;\u00a00\u00b705) compared with the side pre\u2010treated with control. A subgroup analysis showed that the effect of granisetron on pain duration was significant only in women (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0&lt;\u00a00\u00b7001), while the effect on peak pain and pain area were significant in both sexes. The results showed no significant change in\n                    <jats:styled-content style=\"fixed-case\">PPT<\/jats:styled-content>\n                    . In conclusion, these results indicate that granisetron has a pain\u2010reducing effect on experimentally induced muscle pain by repeated acidic saline injection.\n                  <\/jats:p>","DOI":"10.1111\/joor.12046","type":"journal-article","created":{"date-parts":[[2013,3,23]],"date-time":"2013-03-23T16:54:57Z","timestamp":1364057697000},"page":"403-412","source":"Crossref","is-referenced-by-count":11,"title":["Influence of intramuscular granisetron on experimentally induced muscle pain by acidic saline"],"prefix":"10.1111","volume":"40","author":[{"given":"S.","family":"Louca","sequence":"first","affiliation":[{"name":"Section for Orofacial Pain and Jaw Function Department of Dental Medicine Karolinska Institutet Huddinge Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Ernberg","sequence":"additional","affiliation":[{"name":"Section for Orofacial Pain and Jaw Function Department of Dental Medicine Karolinska Institutet Huddinge Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Christidis","sequence":"additional","affiliation":[{"name":"Section for Orofacial Pain and Jaw Function Department of Dental Medicine Karolinska Institutet Huddinge Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,3,23]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(89)90133-4"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.1990.0043"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2005.07.018"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/10454411970080030401"},{"key":"e_1_2_9_6_1","first-page":"169","article-title":"Gender differences in pain","volume":"14","author":"Dao TT","year":"2000","journal-title":"J Orofac Pain"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016350500520276"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(99)00250-7"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2004.09.017"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00419.2005"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.2340\/16501977-0581"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365513.2010.511257"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(93)90027-M"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/03009740410006970"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-03-01010.2002"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-002-0233-8"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/030097402320817103"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/03009740410007032"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/AJP.0b013e318058abb1"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2004.10.016"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(99)00221-3"},{"key":"e_1_2_9_22_1","first-page":"41","article-title":"Human experimental pain models in drug development: translational pain research","volume":"8","author":"Arendt\u2010Nielsen L","year":"2007","journal-title":"Curr Opin Investig Drugs"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2008.05.002"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-2982.1992.1202101.x"},{"key":"e_1_2_9_25_1","first-page":"239","article-title":"Experimental referred pain and hyperalgesia from muscles in humans","volume":"7","author":"Vecchiet L","year":"1993","journal-title":"Elsevier"},{"key":"e_1_2_9_26_1","first-page":"55","article-title":"Effects of noxious stimulation of the jaw muscles on the sensory experience of volunteer human subjects","volume":"29","author":"Stohler CS","year":"1994","journal-title":"Biol. 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