{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T13:16:11Z","timestamp":1788873371209,"version":"build-2803163510"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,3,21]],"date-time":"2014-03-21T00:00:00Z","timestamp":1395360000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Grants-in-Aid for Scientific Research","award":["24593104"],"award-info":[{"award-number":["24593104"]}]},{"name":"Grants-in-Aid for Scientific Research","award":["24390464"],"award-info":[{"award-number":["24390464"]}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Oral Rehabilitation"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Recent studies have been revealing the relationship between the stomatognathic system and the gastrointestinal tract. However, the effect of oesophageal acid stimulation on masticatory muscle activity during wakefulness has not been fully elucidated. To examine whether intra\u2010oesophageal acidification induces masticatory muscle activity, a randomised trial was conducted investigating the effect of oesophageal acid infusion on masseter muscle activity, autonomic nervous system (ANS) activity and subjective symptoms. Polygraphic monitoring consisting of electromyography of the masseter muscle, electrocardiography and audio\u2013video recording was performed in 15 healthy adult men, using three different 30\u2010min interventions: (i) no infusion, (ii) intra\u2010oesophageal saline infusion and (iii) intra\u2010oesophageal infusion of acidic solution (0\u00b71\u00a0N HCl; pH 1\u00b72). This study was registered with the UMIN Clinical Trials Registry, UMIN000005350. Oesophageal acid stimulation significantly increased masseter muscle activity during wakefulness, especially when no behaviour was performed in the oro\u2010facial region. Chest discomfort, including heartburn, also increased significantly after oesophageal acid stimulation; however, no significant correlation was observed between increased subjective symptoms and masseter muscle activity. Oesophageal acid infusion also altered ANS activity; a significant correlation was observed between masticatory muscle changes and parasympathetic nervous system activity. These findings suggest that oesophageal\u2010derived ANS modulation induces masseter muscle activity, irrespective of the presence or absence of subjective gastrointestinal symptoms.<\/jats:p>","DOI":"10.1111\/joor.12159","type":"journal-article","created":{"date-parts":[[2014,3,21]],"date-time":"2014-03-21T13:55:05Z","timestamp":1395410105000},"page":"423-431","source":"Crossref","is-referenced-by-count":9,"title":["Influence of experimental oesophageal acidification on masseter muscle activity, cervicofacial behaviour and autonomic nervous activity in wakefulness"],"prefix":"10.1111","volume":"41","author":[{"given":"H.","family":"Ohmure","sequence":"first","affiliation":[{"name":"Department of Orthodontics Kagoshima University Graduate School of Medical and Dental Sciences Kagoshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Sakoguchi","sequence":"additional","affiliation":[{"name":"Department of Orthodontics Kagoshima University Graduate 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